UBE3C

Gene Symbol UBE3C
Entrez Gene 9690
Alt Symbol HECTH2
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3C
Other Description ubiquitin-protein isopeptide ligase (E3)|ubiquitin-protein ligase E3C
Swissprots Q9UDU3 Q15386 A6NCP3 Q8TC15 Q96CR4 A4D235
Accessions AAD51453 EAL23922 EAX04567 EAX04568 EAX04569 Q15386 AA596042 AK127280 AK295138 BAG58161 BC014029 AAH14029 BC026241 AAH26241 CD366848 D13635 BAA02799 DB085748 DB454915 XM_005249564 XP_005249621 XM_011516714 XP_011515016 XR_927552 NM_014671 NP_055486
Function E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:9575161}.
Top Pathways Ubiquitin mediated proteolysis

UBE3C CRISPR/Cas9 KO Plasmid (h) - sc-410554 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C HDR Plasmid (h) - sc-410554-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C Double Nickase Plasmid (h) - sc-410554-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C Double Nickase Plasmid (h2) - sc-410554-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C CRISPR Activation Plasmid (h) - sc-410554-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C CRISPR Activation Plasmid (h2) - sc-410554-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C Lentiviral Activation Particles (h) - sc-410554-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C Lentiviral Activation Particles (h2) - sc-410554-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE3C siRNA (h) - sc-89538 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE3C shRNA Plasmid (h) - sc-89538-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE3C shRNA (h) Lentiviral Particles - sc-89538-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE3C RNAi - H00009690-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU021021 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22394 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22394 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12702 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12702

UBE3C siRNA (Human) - CRH6462 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBE3C - MBS8237023 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UBE3C (NM_014671.2) - SHH439276 from Creative biogene

Category siRNA
Species Reactivities Human

Human UBE3C siRNA - orb266964 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBE3C shRNA Plasmid (Human) - CHH6462 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBE3C miRNA 3'UTR clone - MiUTR3H-13257 from Creative biogene

Species Reactivities Human
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