UBE3C

Gene Symbol	UBE3C
Entrez Gene	9690
Alt Symbol	HECTH2
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3C
Other Description	ubiquitin-protein isopeptide ligase (E3)|ubiquitin-protein ligase E3C
Swissprots	Q9UDU3 Q15386 A6NCP3 Q8TC15 Q96CR4 A4D235
Accessions	AAD51453 EAL23922 EAX04567 EAX04568 EAX04569 Q15386 AA596042 AK127280 AK295138 BAG58161 BC014029 AAH14029 BC026241 AAH26241 CD366848 D13635 BAA02799 DB085748 DB454915 XM_005249564 XP_005249621 XM_011516714 XP_011515016 XR_927552 NM_014671 NP_055486
Function	E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690}.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:9575161}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE3C full length protein - ab160609 from Abcam Category Protein Source Wheat germ Species Human

Human UBE3C protein fragment - ab160610 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human UBE3C Protein - H00009690-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human UBE3C Protein - H00009690-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UBE3C - H00009690-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBE3C - H00009690-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBE3C - H00009690-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBE3C - H00009690-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBE3C fusion protein - ag2966 from Proteintech Group Category Protein Source E. coli-derived, T-GST Species Human

Recombinant Human Ubiquitin-protein ligase E3C(UBE3C) ,partial - CSB-YP621871HU CSB-EP621871HU CSB-BP621871HU CSB-MP621871HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UBE3C Blocking Peptide - CBP4305 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

UBE3C Blocking Peptide - abx161516 from Abbexa Category Peptide Species Human

UBE3C - TP315110 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UBE3C Recombinant Protein Antigen - NBP1-81558PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UBE3C-Blocking-Peptide-Center - BP20457c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE3C Peptide, Human - M34GP16983H from Creative Peptides Category Peptide Source Synthetic. Species Human

UBE3C peptide - orb304896 from Biorbyt Category Peptide

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