ERN2

Gene Symbol ERN2
Entrez Gene 10595
Alt Symbol IRE1-BETA, IRE1b
Species Human
Gene Type protein-coding
Description endoplasmic reticulum to nucleus signaling 2
Other Description ER to nucleus signalling 2|IRE1 beta|IRE1, S. cerevisiae, homolog of|endoplasmic reticulum to nucleus signalling 2|endoplasmic reticulum-to-nucleus signaling 2|hIRE2p|inositol-requiring 1 beta|inositol-requiring protein 2|serine/threonine-protein kinase/endoribonuclease IRE2
Swissprots Q76MJ5 Q6ZNC0
Accessions EAW55802 Q76MJ5 AB047079 BAB21297 AK131280 BAD18455 AK309313 AK310834 BC156238 AAI56239 BC157113 AAI57114 BU608100 EF560720 ABQ59030 EF560739 ABQ59049 GQ129249 ACT64383 GQ129250 ACT64384 XM_005255044 XP_005255101 XM_011545708 XP_011544010 XM_011545709 XP_011544011 XM_011545710 XP_011544012 XM_011545711 XP_011544013 XM_011545712 XP_011544014 XM_011545713 XP_011544015 XR_950727 NM_001308220 NP_001295149 NM_033266 NP_150296
Function Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}.

IRE1β (H-165) - sc-25563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

IRE1β (D-16) - sc-20576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IRE1β (N-13) - sc-20575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IRE1β (N-13): sc-20575. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic and nuclear staining of cells in glomeruli and cells in tubules.

IRE1β (P-20) - sc-10512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ERN2 antibody - C-terminal - ab71348 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ERN2 antibody - C-terminal (ab71348) at 1/100 dilution + mouse liver tissue lysate at 12.5 µg

Anti-ERN2 antibody - N-terminal - ab135795 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ERN2 antibody - N-terminal (ab135795) at 1/50 dilution + Mouse stomach tissue lysate at 35 µg

Anti-IRE1 (phospho S724) antibody - ab104157 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRE1 (phospho S724) antibody (ab104157) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat Whole Cell Extract (H2O2 treated)Lane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate with Human IRE1 (phospho S724) peptide (ab133861) at 1 µg/mlLane 4 : Jurkat Whole Cell Extract (H2O2 treated) with Human IRE1 (phospho S724) peptide (ab133861) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IRE1 (phospho S724) antibody - ab48187 from Abcam

Prices $401.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRE1 (phospho S724) antibody (ab48187) at 1/1000 dilutionLane 1 : Min6 cells untreatedLane 2 : Min6 cells treated with glucose for 3 hours at 5 mMLane 3 : Min6 cells treated with glucose for 3 hours at 20 mMdeveloped using the ECL technique

Anti-IRE1 (phospho S724) antibody (Biotin) - ab81936 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IRE1 (phospho S724) antibody [EPR5253] - ab124945 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5253
Overlay histogram showing Raji cells stained with ab124945 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab124945, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-IRE1 antibody - ab37073 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-IRE1 antibody (ab37073) at 0.5 µg/mlLane 2 : Anti-IRE1 antibody (ab37073) at 1 µg/mlLane 3 : Anti-IRE1 antibody (ab37073) at 2 µg/mlLane 1 : A20 cell lysateLane 2 : A20 cell lysateLane 3 : A20 cell lysateLysates/proteins at 15 µg per lane.Secondarygoat anti-rabbit HRP at 1/10000 dilution

Anti-IRE1 antibody - ab37117 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRE1 antibody (ab37117)Lane 1 : ab37117 at 0.5µg/ml + A20 cell lysateLane 2 : ab37117 at 1µg/ml + A20 Cell lysateLane 3 : ab37117 at 2µg/ml + A20 cell lysate

Anti-IRE1 antibody - ab77544 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-IRE1 antibody (ab77544) at 0.03 µg/ml + human pancreas lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-IRE1 antibody - ab54692 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IRE1 antibody - ab87964 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-IRE1 antibody (ab87964) at 1 µg/ml + Immunogen (Recombinant protein) at 0.2 µgdeveloped using the ECL technique

Anti-IRE1 antibody - ab62570 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-IRE1 antibody (ab62570) at 1 µg/mlLane 2 : Anti-IRE1 antibody (ab62570) at 2 µg/mlLane 1 : Raji cell lysateLane 2 : Raji cell lysateLysates/proteins at 15 µg per lane.

Anti-IRE1 antibody [9F2] - ab96481 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9F2
All lanes : Anti-IRE1 antibody [9F2] (ab96481) at 1/500 dilutionLane 1 : Raji cell lysateLane 2 : A431 cell lysateLane 3 : Jurkat cell lysateLane 4 : HeLa cell lysateLane 5 : HEK293 cell lysate

Anti-ERN2 Antibody (aa39-72) - LS-C98323 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of ERN2 N-term in mouse stomach tissue lysates (35 ug/lane). ERN2 (arrow) was detected using the purified antibody.

Anti-ERN2 Antibody (aa491-505) - LS-C87282 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ERN2 Antibody (aa883-911, Azide-free, HRP) - LS-C256800 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN2 Antibody (aa883-911, PE) - LS-C256801 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN2 Antibody (aa883-911, APC) - LS-C259290 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN2 Antibody (aa883-911, AP) - LS-C259291 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN2 Antibody (aa883-911, FITC) - LS-C259293 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN2 Antibody (aa883-911, Biotin) - LS-C259292 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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