| Gene Symbol |
ERN2
|
| Entrez Gene |
10595
|
| Alt Symbol |
IRE1-BETA, IRE1b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endoplasmic reticulum to nucleus signaling 2
|
| Other Description |
ER to nucleus signalling 2|IRE1 beta|IRE1, S. cerevisiae, homolog of|endoplasmic reticulum to nucleus signalling 2|endoplasmic reticulum-to-nucleus signaling 2|hIRE2p|inositol-requiring 1 beta|inositol-requiring protein 2|serine/threonine-protein kinase/endoribonuclease IRE2
|
| Swissprots |
Q76MJ5 Q6ZNC0
|
| Accessions |
EAW55802 Q76MJ5 AB047079 BAB21297 AK131280 BAD18455 AK309313 AK310834 BC156238 AAI56239 BC157113 AAI57114 BU608100 EF560720 ABQ59030 EF560739 ABQ59049 GQ129249 ACT64383 GQ129250 ACT64384 XM_005255044 XP_005255101 XM_011545708 XP_011544010 XM_011545709 XP_011544011 XM_011545710 XP_011544012 XM_011545711 XP_011544013 XM_011545712 XP_011544014 XM_011545713 XP_011544015 XR_950727 NM_001308220 NP_001295149 NM_033266 NP_150296
|
| Function |
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}.
|
![Western Blot: ERN2 Overexpression Lysate (Adult Normal) [NBL1-10335] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ERN2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1570_ERN2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10335-img0002.jpg)