Gene Symbol | ERN2 |
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Entrez Gene | 10595 |
Alt Symbol | IRE1-BETA, IRE1b |
Species | Human |
Gene Type | protein-coding |
Description | endoplasmic reticulum to nucleus signaling 2 |
Other Description | ER to nucleus signalling 2|IRE1 beta|IRE1, S. cerevisiae, homolog of|endoplasmic reticulum to nucleus signalling 2|endoplasmic reticulum-to-nucleus signaling 2|hIRE2p|inositol-requiring 1 beta|inositol-requiring protein 2|serine/threonine-protein kinase/endoribonuclease IRE2 |
Swissprots | Q76MJ5 Q6ZNC0 |
Accessions | EAW55802 Q76MJ5 AB047079 BAB21297 AK131280 BAD18455 AK309313 AK310834 BC156238 AAI56239 BC157113 AAI57114 BU608100 EF560720 ABQ59030 EF560739 ABQ59049 GQ129249 ACT64383 GQ129250 ACT64384 XM_005255044 XP_005255101 XM_011545708 XP_011544010 XM_011545709 XP_011544011 XM_011545710 XP_011544012 XM_011545711 XP_011544013 XM_011545712 XP_011544014 XM_011545713 XP_011544015 XR_950727 NM_001308220 NP_001295149 NM_033266 NP_150296 |
Function | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}. |
Active human ERN2 protein fragment - ab190994 from Abcam
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ERN2 Antibody Blocking Peptide - LS-E3890 from LifeSpan Bioscience
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ERN2 Antibody Blocking Peptide - LS-E8705 from LifeSpan Bioscience
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ERN2 Antibody Blocking Peptide - LS-E8706 from LifeSpan Bioscience
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ERN2 Antibody Blocking Peptide - LS-E26728 from LifeSpan Bioscience
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ERN2 Peptide - P2276 from Novus Biologicals
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ERN2 Peptide - P2275 from Novus Biologicals
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ERN2-Antibody-C-term-Blocking-Peptide - BP7128b from Abgent, a WuXi AppTec company
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ERN2-Antibody-N-term-Blocking-Peptide - BP7128a from Abgent, a WuXi AppTec company
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IRE1 beta blocking peptide - GTX88738-PEP from GeneTex
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Goat anti ERN2 antibody Immunizing peptide - orb17151 from Biorbyt
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ERN2 Peptide - AC21-1566-P from Abcore
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ERN2 Peptide - 46-838P from ProSci
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Recombinant Human ERN2, GST-tagged - ERN2-89H from Creative Biomart
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Recombinant Human ERN2 - ERN2-676H from Creative Biomart
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Recombinant Human Serine/threonine-protein kinase/endoribonuclease IRE2(ERN2) ,p - CSB-YP745091HU CSB-EP745091HU CSB-BP745091HU CSB-MP745091HU from Cusabio
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ERN2/IRE1b, Peptide - MBS426883 from MyBioSource
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Recombinant Human ERN2 protein, His-tagged - ERN2-677H from Creative Biomart
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ERN2 Recombinant Protein Antigen - NBP1-83092PEP from Novus Biologicals
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ERN2 Peptide, Human - M34GP05060H from Creative Peptides
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Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2), partial, Recombinant Protein - MBS1327061 from MyBioSource
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