| Gene Symbol |
SCN4B
|
| Entrez Gene |
6330
|
| Alt Symbol |
ATFB17, LQT10, Navbeta4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, voltage gated, type IV beta subunit
|
| Other Description |
sodium channel subunit beta-4|sodium channel, voltage-gated, type IV, beta subunit
|
| Swissprots |
Q6PIG5 E9PPT5 Q8IWT1
|
| Accessions |
ACA06071 EAW67351 EAW67352 Q8IWT1 AK090713 AK092285 AK124886 AK314531 BAG37123 AY149967 AAN74584 BC035017 AAH35017 BX538328 DA109496 DA111034 DA211092 DA247019 DB101246 DB237478 NM_001142348 NP_001135820 NM_001142349 NP_001135821 NM_174934 NP_777594 NR_024527
|
| Function |
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.
|
| Tissue Specificity |
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium. {ECO:0000269|PubMed:12930796, ECO:0000269|PubMed:21051419}.
|
| Top Pathways |
Adrenergic signaling in cardiomyocytes
|