SCN4B

Gene Symbol SCN4B
Entrez Gene 6330
Alt Symbol ATFB17, LQT10, Navbeta4
Species Human
Gene Type protein-coding
Description sodium channel, voltage gated, type IV beta subunit
Other Description sodium channel subunit beta-4|sodium channel, voltage-gated, type IV, beta subunit
Swissprots Q6PIG5 E9PPT5 Q8IWT1
Accessions ACA06071 EAW67351 EAW67352 Q8IWT1 AK090713 AK092285 AK124886 AK314531 BAG37123 AY149967 AAN74584 BC035017 AAH35017 BX538328 DA109496 DA111034 DA211092 DA247019 DB101246 DB237478 NM_001142348 NP_001135820 NM_001142349 NP_001135821 NM_174934 NP_777594 NR_024527
Function Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.
Tissue Specificity Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium. {ECO:0000269|PubMed:12930796, ECO:0000269|PubMed:21051419}.
Top Pathways Adrenergic signaling in cardiomyocytes

Scn4b CRISPR/Cas9 KO Plasmid (h) - sc-411001 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b HDR Plasmid (h) - sc-411001-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b Double Nickase Plasmid (h) - sc-411001-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b Double Nickase Plasmid (h2) - sc-411001-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b CRISPR Activation Plasmid (h) - sc-411001-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b CRISPR Activation Plasmid (h2) - sc-411001-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b Lentiviral Activation Particles (h) - sc-411001-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b Lentiviral Activation Particles (h2) - sc-411001-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Scn4b siRNA (h) - sc-62982 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Scn4b shRNA Plasmid (h) - sc-62982-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Scn4b shRNA (h) Lentiviral Particles - sc-62982-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SCN4B RNAi - H00006330-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU003371 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18956 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18956 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SCN4B siRNA (Human) - CRH4266 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SCN4B - MBS8225200 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SCN4B (NM_174934.3) - SHH402868 from Creative biogene

Category siRNA
Species Reactivities Human

SCN4B shRNA Plasmid (Human) - CHH4266 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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