SCN4B

Gene Symbol SCN4B
Entrez Gene 6330
Alt Symbol ATFB17, LQT10, Navbeta4
Species Human
Gene Type protein-coding
Description sodium channel, voltage gated, type IV beta subunit
Other Description sodium channel subunit beta-4|sodium channel, voltage-gated, type IV, beta subunit
Swissprots Q6PIG5 E9PPT5 Q8IWT1
Accessions ACA06071 EAW67351 EAW67352 Q8IWT1 AK090713 AK092285 AK124886 AK314531 BAG37123 AY149967 AAN74584 BC035017 AAH35017 BX538328 DA109496 DA111034 DA211092 DA247019 DB101246 DB237478 NM_001142348 NP_001135820 NM_001142349 NP_001135821 NM_174934 NP_777594 NR_024527
Function Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.
Tissue Specificity Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium. {ECO:0000269|PubMed:12930796, ECO:0000269|PubMed:21051419}.
Top Pathways Adrenergic signaling in cardiomyocytes

Human SCN4B peptide - ab95413 from Abcam

Category Peptide

Recombinant Human Sodium channel subunit beta-4(SCN4B) - CSB-YP818246HU CSB-EP818246HU CSB-BP818246HU CSB-MP818246HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

SCN4B (transcript variant 1) - TP323951 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
SCN4B

SCN4B Recombinant Protein Antigen - NBP1-86057PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

SCN4B Blocking Peptide - abx061114 from Abbexa

Category Peptide
Species Human

SCN4B Peptide, Human - M34GP13871H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

SCN4B Blocking Peptide - CBP5027 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human

Sodium channel subunit beta-4 (SCN4B), Recombinant Protein - MBS1355318 from MyBioSource

Category Protein
Prices $870.00, $870.00, $1,095.00, $1,095.00, $1,265.00, $1,265.00, $1,725.00, $1,725.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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