SCN4B

Gene Symbol SCN4B
Entrez Gene 6330
Alt Symbol ATFB17, LQT10, Navbeta4
Species Human
Gene Type protein-coding
Description sodium channel, voltage gated, type IV beta subunit
Other Description sodium channel subunit beta-4|sodium channel, voltage-gated, type IV, beta subunit
Swissprots Q6PIG5 E9PPT5 Q8IWT1
Accessions ACA06071 EAW67351 EAW67352 Q8IWT1 AK090713 AK092285 AK124886 AK314531 BAG37123 AY149967 AAN74584 BC035017 AAH35017 BX538328 DA109496 DA111034 DA211092 DA247019 DB101246 DB237478 NM_001142348 NP_001135820 NM_001142349 NP_001135821 NM_174934 NP_777594 NR_024527
Function Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.
Tissue Specificity Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium. {ECO:0000269|PubMed:12930796, ECO:0000269|PubMed:21051419}.
Top Pathways Adrenergic signaling in cardiomyocytes

Scn4b (C-20) - sc-55899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Scn4b (E-17) - sc-55901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SCN4B antibody - ab80539 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SCN4B antibody (ab80539) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Brain (Rat) Tissue Lysate Lane 3 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell Lysate Lane 4 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188)Lane 5 : Spinal Cord (Rat) Tissue Lysate Lane 6 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lysates/proteins at 10 µg/ml per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Observed band size : 37 kDa (why is the actual band size different from the predicted?)Additional bands at : 20 kDa. We are unsure as to the identity of these extra bands.Exposure time : 8 minutes

Anti-SCN4B Antibody (aa6-55) - LS-C200645 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using SCN4B antibody.

Anti-SCN4B Antibody (aa61-110) - LS-C120399 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2/Jurkat cells, using SCN4B Antibody. The lane on the right is treated with the synthesized peptide.

Anti-SCN4B Antibody - LS-C335208 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of U-87 cell lines, using SCN4B antibody.

Anti-SCN4B Antibody - LS-C193078 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of U-87 cell lines, using SCN4B antibody.

SCN4B Antibody - NBP1-86057 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN4B antibody produced in rabbit - HPA017293 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SCN4B: <B>Cat. No. HPA017293</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human small intestine shows moderate positivity in glandular cells.

Anti-SCN4B antibody produced in rabbit - SAB4502714 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SCN4B: <B>Cat. No. SAB4502714</B>: Immunoblotting analysis of extracts from HepG2/Jurkat cells, using Anti-SCN4B antibody. The lane on the left was treated with the Anti-SCN4B antibody. The lane on the right (negative control) was treated with both Anti-SCN4B antibody and the synthesized immunogen peptide.

SCN4B-Antibody - AP50819 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from human skeletal muscle tissue lysate,using SCN4B Antibody. This antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

SCN4B Antibody (OAAF07091) - OAAF07091 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SCN4B Antibody - abx014894 from Abbexa

Host Rabbit
Clonality Polyclonal

SCN4B Antibody - abx001766 from Abbexa

Host Rabbit
Clonality Polyclonal

SCN4B antibody - 55438-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 55438-1-AP( SCN4B Antibody) at dilution of 1:50 (under 10x lens)

Anti-SCN4B, Polyclonal Antibody - 25-A2154 from ARP American Research Products

Prices $299.00, $449.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

Anti-Scn4b antibody - STJ95589 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

SCN4B antibody - 55438-1-AP from Proteintech Group

Prices $279.00
Sizes con: 58 μg/150μl
Host Rabbit
Clonality Polyclonal
mouse heart tissue were subjected to SDS PAGE followed by western blot with 55438-1-AP(SCN4B antibody) at dilution of 1:500

SCN4B - A2154 from NeoScientific

Prices $220.00, $380.00
Sizes 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal

SCN4B Polyclonal Antibody - PA003279-C18808 from Syd Labs

Prices $150.00, $250.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

SCN4B Polyclonal Antibody - PA003279-R12-3483 from Syd Labs

Prices $150.00, $250.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

SCN4B Antibody - 35053 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HepG2 cells and Jurkat cells, using SCN4B antibody #35053.

SCN4B Polyclonal Antibody - E90110A from Enogene

Prices $255.00
Sizes 100μg/100μl
Host Rabbit
Clonality Polyclonal

SCN4B Antibody - C18808 from Assay Biotechnology

Prices $175.00, $275.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from HepG2 and Jurkat cells, using SCN4B Antibody. The lane on the right is blocked with the synthesized peptide.

SCN4B Antibody - R12-3483 from Assay Biotechnology

Prices $175.00, $275.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of the lysates from HeLa cells using SCN4B antibody.
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