UBR5

Gene Symbol UBR5
Entrez Gene 51366
Alt Symbol DD5, EDD, EDD1, HYD
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3 component n-recognin 5
Other Description E3 identified by differential display|E3 ubiquitin protein ligase, HECT domain containing, 1|E3 ubiquitin-protein ligase UBR5|E3 ubiquitin-protein ligase, HECT domain-containing 1|hyperplastic discs protein homolog|progestin induced protein|progestin-induced protein|ubiquitin-protein ligase
Swissprots O94970 J3KMW7 B2RP24 Q9NPL3 O95071
Accessions CCQ43525 EAW91843 EAW91844 EAW91845 EAW91846 O95071 AB020703 BAA74919 AF006010 AAD01259 AK002172 BAG51024 AK124995 AL833555 BC037843 BC044598 AAH44598 BC053948 BC137234 AAI37235 BC151231 BX489192 U95000 AAF88143 XM_005250962 XP_005251019 XM_011517104 XP_011515406 XM_011517105 XP_011515407 XM_011517106 XP_011515408 NM_015902 NP_056986 NM_001282873 NP_001269802
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:00
Subcellular Location Nucleus.
Tissue Specificity Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Top Pathways Ubiquitin mediated proteolysis

Mouse/Human UBR5 ELISA Kit (Cell-Based ELISA) - LS-F1952 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Human HYD ELISA Kit - HH0322 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine HYD ELISA Kit - AH0322 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

EDD Colorimetric Cell-Based ELISA Kit - CB5219 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

HYD (Hydrocortisone) ELISA Kit - E-EL-0024 from Elabscience

Category ELISA Kit
Range ~

E3/ubiquitin protein ligase, ELISA Kit - MBS720609 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS030722 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS745988 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS744456 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS743692 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

E3/ubiquitin-protein ligase, ELISA Kit - MBS755490 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS737319 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS094759 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS010798 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS107313 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS745269 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS013631 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS747331 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS751172 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS747082 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS720974 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS045137 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS731488 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/Ubiquitin-Protein Ligase, ELISA Kit - MBS064373 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3/ubiquitin-protein ligase, ELISA Kit - MBS723064 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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