| Gene Symbol |
UBR5
|
| Entrez Gene |
51366
|
| Alt Symbol |
DD5, EDD, EDD1, HYD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin protein ligase E3 component n-recognin 5
|
| Other Description |
E3 identified by differential display|E3 ubiquitin protein ligase, HECT domain containing, 1|E3 ubiquitin-protein ligase UBR5|E3 ubiquitin-protein ligase, HECT domain-containing 1|hyperplastic discs protein homolog|progestin induced protein|progestin-induced protein|ubiquitin-protein ligase
|
| Swissprots |
O94970 J3KMW7 B2RP24 Q9NPL3 O95071
|
| Accessions |
CCQ43525 EAW91843 EAW91844 EAW91845 EAW91846 O95071 AB020703 BAA74919 AF006010 AAD01259 AK002172 BAG51024 AK124995 AL833555 BC037843 BC044598 AAH44598 BC053948 BC137234 AAI37235 BC151231 BX489192 U95000 AAF88143 XM_005250962 XP_005251019 XM_011517104 XP_011515406 XM_011517105 XP_011515407 XM_011517106 XP_011515408 NM_015902 NP_056986 NM_001282873 NP_001269802
|
| Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:00
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|