UBR5

Gene Symbol UBR5
Entrez Gene 51366
Alt Symbol DD5, EDD, EDD1, HYD
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3 component n-recognin 5
Other Description E3 identified by differential display|E3 ubiquitin protein ligase, HECT domain containing, 1|E3 ubiquitin-protein ligase UBR5|E3 ubiquitin-protein ligase, HECT domain-containing 1|hyperplastic discs protein homolog|progestin induced protein|progestin-induced protein|ubiquitin-protein ligase
Swissprots O94970 J3KMW7 B2RP24 Q9NPL3 O95071
Accessions CCQ43525 EAW91843 EAW91844 EAW91845 EAW91846 O95071 AB020703 BAA74919 AF006010 AAD01259 AK002172 BAG51024 AK124995 AL833555 BC037843 BC044598 AAH44598 BC053948 BC137234 AAI37235 BC151231 BX489192 U95000 AAF88143 XM_005250962 XP_005251019 XM_011517104 XP_011515406 XM_011517105 XP_011515407 XM_011517106 XP_011515408 NM_015902 NP_056986 NM_001282873 NP_001269802
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:00
Subcellular Location Nucleus.
Tissue Specificity Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Top Pathways Ubiquitin mediated proteolysis

UBR5 Antibody - 8755 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using UBR5 Antibody.

EDD (H-300) - sc-367559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

EDD (N-19) - sc-9561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EDD (N-19): sc-9561. Western blot analysis of EDD expression in IMR-32 nuclear extract.

EDD (M-19) - sc-9562 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EDD antibody - ab175810 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells labelling EDD with ab175810 at 1:1000. Cells were fixed with PFA and permeabilized with methanol for 2 minutes. Cells were incubated with the primary anitbody overnight at room temperature. Top - EDD, Middle - DAPI, Bottom - Merge.

Anti-EDD antibody - ab38867 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EDD antibody (ab38867) at 1/60 dilution + Jurkat cell line lysate at 35 µgObserved band size : 28 kDa (why is the actual band size different from the predicted?)

Anti-EDD antibody [EPR4841] - ab134089 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4841
All lanes : Anti-EDD antibody [EPR4841] (ab134089) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HeLa cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-rabbit at 1/2000 dilution

Anti-UBR5 Antibody (aa1-227) - LS-C143828 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-UBR5 Antibody (C-Terminus, AP) - LS-C244261 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (C-Terminus, APC) - LS-C244262 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (aa69-79) IHC-plus™ - LS-B5908 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-UBR5 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5908 concentration 3.75 ug/ml.

Anti-UBR5 Antibody (Internal, clone EPR4841) - LS-C138453 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4841
Western blot analysis on (A) SH-SY5Y, (B) HeLa, and (C) 293T cell lysates using anti-URB5 antibody. Note: Dilute primary antibody in 1% BSA.

Anti-UBR5 Antibody (C-Terminus, Biotin) - LS-C244263 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (aa600-650) IHC-plus™ - LS-B5219 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UBR5 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5219 concentration 5 ug/ml.

Anti-UBR5 Antibody (C-Terminus, FITC) - LS-C244264 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (C-Terminus, PE) - LS-C244265 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (C-Terminus, Azide-free, HRP) - LS-C247557 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (aa2749-2799) - LS-C289749 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (aa14-63) - LS-C291900 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (aa600-650) - LS-C290206 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (C-Terminus) - LS-C327257 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR5 Antibody (aa600-650) - LS-C286302 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EDD1 by Immunohistochemistry. Sample: FFPE section of human breast adenocarcinoma. Antibody: Affinity purified rabbit anti-EDD1 used at a dilution of 1:100. Detection: DAB.

Anti-UBR5 Antibody (Thr14) - LS-C176336 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of EDD (T14) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-UBR5 Antibody (aa600-650) - LS-C287454 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EDD1 by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-EDD1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-UBR5 Antibody (aa1-50) IHC-plus™ - LS-B7629 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UBR5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7629 concentration 10 ug/ml.
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