UBR5

Gene Symbol	UBR5
Entrez Gene	51366
Alt Symbol	DD5, EDD, EDD1, HYD
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 5
Other Description	E3 identified by differential display|E3 ubiquitin protein ligase, HECT domain containing, 1|E3 ubiquitin-protein ligase UBR5|E3 ubiquitin-protein ligase, HECT domain-containing 1|hyperplastic discs protein homolog|progestin induced protein|progestin-induced protein|ubiquitin-protein ligase
Swissprots	O94970 J3KMW7 B2RP24 Q9NPL3 O95071
Accessions	CCQ43525 EAW91843 EAW91844 EAW91845 EAW91846 O95071 AB020703 BAA74919 AF006010 AAD01259 AK002172 BAG51024 AK124995 AL833555 BC037843 BC044598 AAH44598 BC053948 BC137234 AAI37235 BC151231 BX489192 U95000 AAF88143 XM_005250962 XP_005251019 XM_011517104 XP_011515406 XM_011517105 XP_011515407 XM_011517106 XP_011515408 NM_015902 NP_056986 NM_001282873 NP_001269802
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:00
Subcellular Location	Nucleus.
Tissue Specificity	Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EDD peptide - ab23029 from Abcam Category Peptide Species Human

Human EDD protein fragment - ab153350 from Abcam Category Protein Source Wheat germ Species Human

UBR5 Blocking Peptide - LS-E6850 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBR5 Antibody Blocking Peptide - LS-E25530 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBR5/EDD Protein - H00051366-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UBR5/EDD Peptide - P0864 from Novus Biologicals Category Peptide Species Human

UBR5/EDD Peptide - P0863 from Novus Biologicals Category Peptide Species Human

EDD-Antibody-Center-Blocking-Peptide - BP2101c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EDD-Antibody-C-term-Blocking-Peptide - BP2101b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EDD blocking peptide - GTX89818-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Rat, Bovine

HIP2 blocking peptide - GTX89722-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Bovine

UBR5 Blocking Peptide - abx063860 from Abbexa Category Peptide Species Human, Mouse, Bovine, Dog, Pig, Zebrafish

EDD Peptide - AC21-0359-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UBR5 / HYD - H00051366-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBR5 / HYD - H00051366-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EDD1 Peptide - 45-518P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat, Mouse, Rabbit

UBR5 fusion protein - ag18125 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

UBR5 fusion protein - Ag18753 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

UBR5 Blocking Peptide - CBP2666 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Bovine, Dog, Pig, Zebrafish

HYD (T14) Peptide - BS1460P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human E3 ubiquitin-protein ligase UBR5(UBR5) ,partial - CSB-YP025520HU CSB-EP025520HU CSB-BP025520HU CSB-MP025520HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EDD1/HYD, Peptide - MBS426448 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Pig, Bovine

UBR5/EDD Protein - NBP1-85274PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

UBR5 Peptide, Human - M34GP17007H from Creative Peptides Category Peptide Source Synthetic. Species Human

UBR5 peptide - orb218529 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Zebrafish, Drosophila

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