| Gene Symbol |
HRH2
|
| Entrez Gene |
3274
|
| Alt Symbol |
H2R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histamine receptor H2
|
| Other Description |
HH2R|gastric receptor 1|gastric receptor I|histamine H2 receptor
|
| Swissprots |
Q14464 B5BUP7 Q7Z5R9 P25021
|
| Accessions |
AAA58647 BAA08618 BAA84279 BAA94469 CAA66832 EAW61369 P25021 AB023487 AB451483 BAG70297 AY136744 AAN01270 BC054510 AAH54510 CF147823 XM_005265904 XP_005265961 XM_006714864 XP_006714927 XM_006714865 XP_006714928 XM_011534548 XP_011532850 XM_011534549 XP_011532851 XR_245274 NM_001131055 NP_001124527 NM_022304 NP_071640
|
| Function |
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction
|
![Western Blot: HRH2 Overexpression Lysate (Adult Normal) [NBP2-06453] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HRH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10609_HRH2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06453-img0001.jpg)