RPS6KA2

Gene Symbol RPS6KA2
Entrez Gene 6196
Alt Symbol HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3
Species Human
Gene Type protein-coding
Description ribosomal protein S6 kinase, 90kDa, polypeptide 2
Other Description 90 kDa ribosomal protein S6 kinase 2|MAP kinase-activated protein kinase 1c|MAPK-activated protein kinase 1c|MAPKAP kinase 1c|MAPKAPK-1c|RSK-3|S6K-alpha-2|p90-RSK 2|p90RSK2|ribosomal S6 kinase 3|ribosomal protein S6 kinase 90kDa polypeptide 2|ribosomal protein S6 kinase alpha 2|ribosomal protein S6 kinase alpha-2
Swissprots Q96J38 Q59GJ3 Q9UJN5 B3KTK9 Q15349 Q5TI68 Q15419
Accessions CAC07738 EAW47522 EAW47523 EAW47524 Q15349 AA588877 AB073884 AB209116 BAD92353 AF140710 AK027727 AK095751 BAG53121 AK295674 BAH12151 AK307470 AK310428 BC002363 AAH02363 BC011189 BF205134 BF339000 BI836819 BQ029058 BU160797 BU617697 DQ585489 DQ891864 ABM82790 DQ895053 ABM85979 KJ534936 AHW56576 KJ535080 AHW56719 KJ535087 AHW56726 L07598 AAC82496 X85106 CAA59427 XM_005267092 XP_005267149 XM_006715549 XP_006715612 XM_011536059 XP_011534361 XM_011536060 XP_011534362 XM_011536061 XP_011534363 NM_001006932 NP_001006933 NM_021135 NP_066958
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Subcellular Location Nucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
Tissue Specificity Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Top Pathways Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

RSK3 Antibody - 9343 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of purified RSK1, RSK2 and RSK3 proteins using RSK1 Antibody #9333 (upper), RSK2 Antibody #9340 (middle) or RSK3 Antibody (lower).

Phospho-RSK3 (Thr353/356) Antibody - 9345 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Rsk-3 (C-20) - sc-1431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rsk-3 (C-20): sc-1431. Western blot analysis of Rsk-3 expression in NIH/3T3 (A), Mv 1 Lu (B), A-431 (C), HeLa (D) and MCF7 (E) whole cell lysates.

Rsk-3 (A-16) - sc-13379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rsk-3 (A-16): sc-13379. Western blot analysis of Rsk-3 expression in non-transfected: sc-117752 (A) and human Rsk-3 transfected: sc-176241 (B) 293T whole cell lysates.

Rsk-3 (N-16) - sc-13378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Rsk (Ser 376) - sc-12883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of λphosphatase-treated (A,C,E) and untreated (B,D,F) active human recombinant Rsk. Antibodies tested include Rsk-1 (C-21): sc-231 (A,B), p-Rsk (Ser 376): sc-12883 (C,D) and p-Rsk (Ser 376)-R: sc-12883-R (E,F).

Anti-RSK3 (phospho T353 + T356) antibody - ab138361 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RSK3 (phospho T353 + T356) antibody (ab138361) at 1/500 dilution + HeLa cell extract at 30 µg

Anti-RSK3 antibody - ab115037 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-RSK3 antibody (ab115037) at 0.01 µg/ml + Rat lung lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-RSK3 antibody - ab42934 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RSK3 antibody (ab42934) at 1/1000 dilution + Rat hippocampal lysate at 20 µg/mlSecondaryGoat-anti-rabbit HRP at 1/15000 dilutionObserved band size : 90 kDa (why is the actual band size different from the predicted?)

Anti-RSK3 antibody - ab185999 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Human RSK by Western Blot of Immunoprecipitates of HeLawhole cell lysate (1 mg for IP; 20% of IP loaded) .Lane 1: ab185999 used for IP at 6 μg/mg lysate.Lane 2: Control IgG.For blotting an anti-RSK antibody was used at 1 μg/ml.Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-RSK3 antibody - ab186023 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of RSK3 in immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab186023 at 6 µg/mg lysate for IP (Lane 1). Lane 2 represents rabbit IgG IP control. Subsequent Western blot detection of RSK3 was performed using ab186023 at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-RSK3 antibody - ab135962 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RSK3 antibody (ab135962) at 1/500 dilution + 293 cell extract at 30 µg

Anti-RSK3 antibody [3A3] - ab77126 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A3
All lanes : Anti-RSK3 antibody [3A3] (ab77126) at 1/2000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat T cell lysateLane 3 : RD cell lysate

Anti-RSK3 antibody [3C1] - ab70901 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C1
All lanes : Anti-RSK3 antibody [3C1] (ab70901) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysateLane 3 : Hut78 cell lysateLane 4 : L929 cell lysateLane 5 : C6 cell lysate

Anti-RSK3 antibody [3C4C8] - C-terminal - ab201988 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C4C8
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling RSK3 with ab201988 at 1/200 dilution.

Anti-RSK3 antibody [E202] - ab32563 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E202
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using ab32563 at 1/50 dilution.

Anti-RPS6KA2 / RSK3 Antibody (C-Terminus) - LS-C17732 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA2 / RSK3 Antibody (Pro709) - LS-C75548 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA2 / RSK3 Antibody (Asp659) - LS-C38958 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA2 / RSK3 Antibody (aa191-218, Biotin) - LS-C285135 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA2 / RSK3 Antibody (aa191-218, APC) - LS-C285136 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA2 / RSK3 Antibody (aa241-290) - LS-C119057 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human thyroid gland tissue, using S6K-alpha2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-RPS6KA2 / RSK3 Antibody (aa191-218, AP) - LS-C285137 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA2 / RSK3 Antibody (phospho-Thr353/Thr356, clone E202) - LS-C49965 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E202
IHC of paraffin-embedded human prostate carcinoma using anti-Phospho-Rsk3 (pT353/356) antibody.

Anti-RPS6KA2 / RSK3 Antibody (aa191-218, FITC) - LS-C285138 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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