RPS6KA2

Gene Symbol	RPS6KA2
Entrez Gene	6196
Alt Symbol	HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 2
Other Description	90 kDa ribosomal protein S6 kinase 2|MAP kinase-activated protein kinase 1c|MAPK-activated protein kinase 1c|MAPKAP kinase 1c|MAPKAPK-1c|RSK-3|S6K-alpha-2|p90-RSK 2|p90RSK2|ribosomal S6 kinase 3|ribosomal protein S6 kinase 90kDa polypeptide 2|ribosomal protein S6 kinase alpha 2|ribosomal protein S6 kinase alpha-2
Swissprots	Q96J38 Q59GJ3 Q9UJN5 B3KTK9 Q15349 Q5TI68 Q15419
Accessions	CAC07738 EAW47522 EAW47523 EAW47524 Q15349 AA588877 AB073884 AB209116 BAD92353 AF140710 AK027727 AK095751 BAG53121 AK295674 BAH12151 AK307470 AK310428 BC002363 AAH02363 BC011189 BF205134 BF339000 BI836819 BQ029058 BU160797 BU617697 DQ585489 DQ891864 ABM82790 DQ895053 ABM85979 KJ534936 AHW56576 KJ535080 AHW56719 KJ535087 AHW56726 L07598 AAC82496 X85106 CAA59427 XM_005267092 XP_005267149 XM_006715549 XP_006715612 XM_011536059 XP_011534361 XM_011536060 XP_011534362 XM_011536061 XP_011534363 NM_001006932 NP_001006933 NM_021135 NP_066958
Function	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
Tissue Specificity	Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Top Pathways	Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rsk-3 CRISPR/Cas9 KO Plasmid (h) - sc-402556 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 HDR Plasmid (h) - sc-402556-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 Double Nickase Plasmid (h) - sc-402556-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 Double Nickase Plasmid (h2) - sc-402556-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 CRISPR Activation Plasmid (h) - sc-402556-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 CRISPR Activation Plasmid (h2) - sc-402556-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 Lentiviral Activation Particles (h) - sc-402556-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 Lentiviral Activation Particles (h2) - sc-402556-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-3 siRNA (h) - sc-36443 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rsk-3 shRNA Plasmid (h) - sc-36443-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rsk-3 shRNA (h) Lentiviral Particles - sc-36443-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RSK3 RNAi - H00006196-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RSK3 RNAi - H00006196-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU007431 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2007 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2009 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2008 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN18654 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18654 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RPS6KA2 siRNA (Human) - CRH4171 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RSK3 RNAi - H00006196-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RPS6KA2 - MBS8220924 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RPS6KA2 (NM_021135.4) - SHH399552 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RPS6KA2(NM_001006932.1) - SHR197280 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RPS6KA2(NM_021135.4) - SHR197646 from Creative biogene Category siRNA Species Reactivities Human

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