| Gene Symbol |
RPS6KA2
|
| Entrez Gene |
6196
|
| Alt Symbol |
HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribosomal protein S6 kinase, 90kDa, polypeptide 2
|
| Other Description |
90 kDa ribosomal protein S6 kinase 2|MAP kinase-activated protein kinase 1c|MAPK-activated protein kinase 1c|MAPKAP kinase 1c|MAPKAPK-1c|RSK-3|S6K-alpha-2|p90-RSK 2|p90RSK2|ribosomal S6 kinase 3|ribosomal protein S6 kinase 90kDa polypeptide 2|ribosomal protein S6 kinase alpha 2|ribosomal protein S6 kinase alpha-2
|
| Swissprots |
Q96J38 Q59GJ3 Q9UJN5 B3KTK9 Q15349 Q5TI68 Q15419
|
| Accessions |
CAC07738 EAW47522 EAW47523 EAW47524 Q15349 AA588877 AB073884 AB209116 BAD92353 AF140710 AK027727 AK095751 BAG53121 AK295674 BAH12151 AK307470 AK310428 BC002363 AAH02363 BC011189 BF205134 BF339000 BI836819 BQ029058 BU160797 BU617697 DQ585489 DQ891864 ABM82790 DQ895053 ABM85979 KJ534936 AHW56576 KJ535080 AHW56719 KJ535087 AHW56726 L07598 AAC82496 X85106 CAA59427 XM_005267092 XP_005267149 XM_006715549 XP_006715612 XM_011536059 XP_011534361 XM_011536060 XP_011534362 XM_011536061 XP_011534363 NM_001006932 NP_001006933 NM_021135 NP_066958
|
| Function |
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
|
| Tissue Specificity |
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
|
| Top Pathways |
Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis
|
![Western Blot: RSK3 Overexpression Lysate (Adult Normal) [NBL1-15571] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RSK3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3408_RSK3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15571-img0002.jpg)