RPS6KA2

Gene Symbol	RPS6KA2
Entrez Gene	6196
Alt Symbol	HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 2
Other Description	90 kDa ribosomal protein S6 kinase 2|MAP kinase-activated protein kinase 1c|MAPK-activated protein kinase 1c|MAPKAP kinase 1c|MAPKAPK-1c|RSK-3|S6K-alpha-2|p90-RSK 2|p90RSK2|ribosomal S6 kinase 3|ribosomal protein S6 kinase 90kDa polypeptide 2|ribosomal protein S6 kinase alpha 2|ribosomal protein S6 kinase alpha-2
Swissprots	Q96J38 Q59GJ3 Q9UJN5 B3KTK9 Q15349 Q5TI68 Q15419
Accessions	CAC07738 EAW47522 EAW47523 EAW47524 Q15349 AA588877 AB073884 AB209116 BAD92353 AF140710 AK027727 AK095751 BAG53121 AK295674 BAH12151 AK307470 AK310428 BC002363 AAH02363 BC011189 BF205134 BF339000 BI836819 BQ029058 BU160797 BU617697 DQ585489 DQ891864 ABM82790 DQ895053 ABM85979 KJ534936 AHW56576 KJ535080 AHW56719 KJ535087 AHW56726 L07598 AAC82496 X85106 CAA59427 XM_005267092 XP_005267149 XM_006715549 XP_006715612 XM_011536059 XP_011534361 XM_011536060 XP_011534362 XM_011536061 XP_011534363 NM_001006932 NP_001006933 NM_021135 NP_066958
Function	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
Tissue Specificity	Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Top Pathways	Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RSK3 full length protein - ab60882 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human RSK3 full length protein - ab152665 from Abcam Category Protein Source Wheat germ Species Human

Human RSK3 protein fragment - ab152666 from Abcam Category Protein Source Wheat germ Species Human

RPS6KA2 / RSK3 Antibody Blocking Peptide - LS-E5033 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPS6KA2 / RSK3 Antibody Blocking Peptide - LS-E20346 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RSK3 Protein - H00006196-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human RSK3 Protein - H00006196-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RSK3 Recombinant Protein - P4263 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant RSK3 Protein - NBP1-99503 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

p90 RSK1 (Active) recombinant protein - GTX65230 from GeneTex Category Protein Prices $389.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

RSK3 (Active) recombinant protein - GTX65231 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human RSK3 GST tag protein - orb84210 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

RPS6KA2 Blocking Peptide - 33R-5450 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RSK3 protein - 30R-2883 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

RSK3 Peptide - AC21-1679-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RPS6KA2 / RSK3 - H00006196-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

RPS6KA2 / RSK3 - H00006196-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPS6KA2 / RSK3 - H00006196-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPS6KA2 / RSK3 - P4263 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

RPS6KA2 Peptide - 42-756P from ProSci Category Peptide Species Rat

RPS6KA2 fusion protein - Ag6079 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RPS6KA2 fusion protein - Ag5862 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RPS6KA2, GST-tagged, Active - RPS6KA2-426H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human RPS6KA2, GST tagged - RPS6KA2-961H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human RPS6KA2, His-tagged - RPS6KA2-2433H from Creative Biomart Category Protein Source E.coli Species Human

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