COL8A2

Gene Symbol COL8A2
Entrez Gene 1296
Alt Symbol FECD, FECD1, PPCD, PPCD2
Species Human
Gene Type protein-coding
Description collagen, type VIII, alpha 2
Other Description collagen VIII, alpha-2 polypeptide|collagen alpha-2(VIII) chain|endothelial collagen
Swissprots Q8TEJ5 Q5JV31 P25067
Accessions AAA62822 AGN55423 AGN55424 AGN55425 AGN55426 AGN55427 AGN55428 AGN55429 AGN55430 EAX07388 P25067 AI084614 AK074129 BAB84955 AK090924 BC096295 AAH96295 BC096296 AAH96296 BC096297 AAH96297 BC099645 AAH99645 HY025990 XM_005270477 XP_005270534 NM_001294347 NP_001281276 NM_005202 NP_005193
Function Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). {ECO:0000250}.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. {ECO:0000269|PubMed:10686422, ECO:0000269|PubMed:17888087}.

COL8A2-Over-expression-Lysate - LY12404a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag COL8A2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the COL8A2 gene

COL8A2 overexpression lysate - LY401592 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

COL8A2 293 Cell Lysate - 401442 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

COL8A2 Overexpression Lysate (Native) - NBL1-09359 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

COL8A2 Over-expression Lysate Product - GWB-32137F from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Panoply™ Human COL8A2 Knockdown Stable Cell Line - CSC-DC003471 from Creative biogene

Category Cell Line
Species Human
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