Gene Symbol | COL8A2 |
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Entrez Gene | 1296 |
Alt Symbol | FECD, FECD1, PPCD, PPCD2 |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type VIII, alpha 2 |
Other Description | collagen VIII, alpha-2 polypeptide|collagen alpha-2(VIII) chain|endothelial collagen |
Swissprots | Q8TEJ5 Q5JV31 P25067 |
Accessions | AAA62822 AGN55423 AGN55424 AGN55425 AGN55426 AGN55427 AGN55428 AGN55429 AGN55430 EAX07388 P25067 AI084614 AK074129 BAB84955 AK090924 BC096295 AAH96295 BC096296 AAH96296 BC096297 AAH96297 BC099645 AAH99645 HY025990 XM_005270477 XP_005270534 NM_001294347 NP_001281276 NM_005202 NP_005193 |
Function | Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. |
Tissue Specificity | Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. {ECO:0000269|PubMed:10686422, ECO:0000269|PubMed:17888087}. |
COL8A2 (G-20) - sc-82841 from Santa Cruz Biotechnology
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COL8A2 (N-16) - sc-82843 from Santa Cruz Biotechnology
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COL8A2 (H-45) - sc-134947 from Santa Cruz Biotechnology
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COL8A2 (P-15) - sc-82844 from Santa Cruz Biotechnology
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Anti-COL8A2 antibody - ab111409 from Abcam
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Anti-COL8A2 antibody - ab112110 from Abcam
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607, AP) - LS-C208540 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607, Biotin) - LS-C208542 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607, APC) - LS-C208541 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607, Azide-free, HRP) - LS-C208544 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607, PE) - LS-C208545 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607, FITC) - LS-C208543 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa537-703, Biotin) - LS-C299754 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (clone 1F4) - LS-C196947 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa469-518) - LS-C135697 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa537-703, FITC) - LS-C303172 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa533-698, Biotin) - LS-C299756 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607) - LS-C329411 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa533-698, FITC) - LS-C303174 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa285-334) - LS-C135494 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa533-698) - LS-C293440 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa537-703) - LS-C294084 from LifeSpan Bioscience
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Anti-COL8A2 / Collagen VIII Antibody (aa578-607) - LS-C166931 from LifeSpan Bioscience
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COL8A2 Antibody - NBP2-30020 from Novus Biologicals
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COL8A2 Antibody - NBP1-79787 from Novus Biologicals
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