| Gene Symbol | COL8A2 |
|---|---|
| Entrez Gene | 1296 |
| Alt Symbol | FECD, FECD1, PPCD, PPCD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | collagen, type VIII, alpha 2 |
| Other Description | collagen VIII, alpha-2 polypeptide|collagen alpha-2(VIII) chain|endothelial collagen |
| Swissprots | Q8TEJ5 Q5JV31 P25067 |
| Accessions | AAA62822 AGN55423 AGN55424 AGN55425 AGN55426 AGN55427 AGN55428 AGN55429 AGN55430 EAX07388 P25067 AI084614 AK074129 BAB84955 AK090924 BC096295 AAH96295 BC096296 AAH96296 BC096297 AAH96297 BC099645 AAH99645 HY025990 XM_005270477 XP_005270534 NM_001294347 NP_001281276 NM_005202 NP_005193 |
| Function | Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. |
| Tissue Specificity | Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. {ECO:0000269|PubMed:10686422, ECO:0000269|PubMed:17888087}. |
COL8A2 CRISPR/Cas9 KO Plasmid (h) - sc-403831 from Santa Cruz Biotechnology
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COL8A2 HDR Plasmid (h) - sc-403831-HDR from Santa Cruz Biotechnology
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COL8A2 Double Nickase Plasmid (h) - sc-403831-NIC from Santa Cruz Biotechnology
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COL8A2 Double Nickase Plasmid (h2) - sc-403831-NIC-2 from Santa Cruz Biotechnology
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COL8A2 CRISPR Activation Plasmid (h) - sc-403831-ACT from Santa Cruz Biotechnology
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COL8A2 CRISPR Activation Plasmid (h2) - sc-403831-ACT-2 from Santa Cruz Biotechnology
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COL8A2 Lentiviral Activation Particles (h) - sc-403831-LAC from Santa Cruz Biotechnology
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COL8A2 Lentiviral Activation Particles (h2) - sc-403831-LAC-2 from Santa Cruz Biotechnology
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COL8A2 siRNA (h) - sc-72951 from Santa Cruz Biotechnology
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COL8A2 shRNA Plasmid (h) - sc-72951-SH from Santa Cruz Biotechnology
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COL8A2 shRNA (h) Lentiviral Particles - sc-72951-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU155251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6405 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6405 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11256 from Sigma-Aldrich
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COL8A2 siRNA (Human) - CRH0910 from Cohesion Biosciences
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COL8A2 - MBS8205057 from MyBioSource
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shRNA set against Human COL8A2 (NM_005202.2) - SHH267461 from Creative biogene
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Human COL8A2 siRNA - orb261412 from Biorbyt
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COL8A2 shRNA Plasmid (Human) - CHH0910 from Cohesion Biosciences
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COL8A2 miRNA 3'UTR clone - MiUTR4H-TG02257 from Creative biogene
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