CES1

Gene Symbol CES1
Entrez Gene 1066
Alt Symbol ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
Species Human
Gene Type protein-coding
Description carboxylesterase 1
Other Description acyl coenzyme A:cholesterol acyltransferase|acyl-coenzyme A:cholesterol acyltransferase|brain carboxylesterase hBr1|carboxylesterase 1 (monocyte/macrophage serine esterase 1)|carboxylesterase 2 (liver)|cholesteryl ester hydrolase|cocaine carboxylesterase|egasyn|human monocyte/macrophage serine esterase 1|liver carboxylesterase 1|methylumbelliferyl-acetate deacetylase 1|monocyte/macrophage serine esterase|retinyl ester hydrolase|serine esterase 1|triacylglycerol hydrolase
Swissprots Q16788 Q16737 Q13657 Q00015 Q9ULY2 Q9UDG8 Q96EE8 Q9UK77 Q9UC52 P82127 Q86UK2 A8K3K8 A8K844 Q549X7 A6NIM1 E9PAU8 Q14062 P23141 Q549X8
Accessions BAA04650 BAC87750 BAC87751 BAE48735 BAE48737 BAE48738 BAE48739 BAE48740 CAA65527 EAW82838 EAW82839 EAW82840 P23141 AB025026 BAA84995 AB119995 BAC87748 AB119996 BAC87749 AF177775 AAD53175 AK290623 BAF83312 AK292209 BAF84898 AK301651 BAH13531 AU139632 AY268104 AAP20868 BC009706 BC012418 AAH12418 BC110338 AAI10339 CB137639 DQ891472 ABM82398 DQ894656 ABM85582 L07764 AAA16036 L07765 AAA35711 M55509 AAA35650 M65261 AAA83932 M73499 AAA35649 S73751 AAC60631 X52973 CAA37147 XM_005255774 XP_005255831 XM_005276867 XP_005276924 XM_011522816 XP_011521118 XM_011546995 XP_011545297 NM_001025194 NP_001020365 NM_001025195 NP_001020366 NM_001266 NP_001257
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. {ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000269|PubMed:10562416}.
Tissue Specificity Expressed predominantly in liver with lower levels in heart and lung. {ECO:0000269|PubMed:10562416}.
Top Pathways Drug metabolism - other enzymes

CES1 (A-11) - sc-365249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CES1 (A-11): sc-365249. Western blot analysis of CES1 expression in Hep G2 whole cell lysate.

CES1 (B-4) - sc-398236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CES1 (B-4): sc-398236. Western blot analysis of CES1 expression in human liver tissue extract.

CES1 (C-13) - sc-55913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CES1 (C-13): sc-55913. Western blot analysis of CES1 expression in non-transfected: sc-117752 (A) and human CES1 transfected: sc-111916 (B) 293T whole cell lysates.

CES1 (E-1) - sc-365248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CES1 (E-1): sc-365248. Western blot analysis of CES1 expression in Hep G2 whole cell lysate.

CES1 (H-95) - sc-135021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CES1 (H-95): sc-135021. Western blot analysis of CES1 expression in non-transfected 293T: sc-117752 (A), human CES1 transfected 293T: sc-111916 (B) and Hep G2 (C) whole cell lysates.

CES1 (L-15) - sc-55918 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CES1 (L-15): sc-55918. Western blot analysis of CES1 expression in non-transfected: sc-117752 (A) and human CES1 transfected: sc-113079 (B) 293T whole cell lysates.

CES1 (S-16) - sc-55921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CES1 (S-16): sc-55921. Western blot analysis of CES1 expression in non-transfected: sc-117752 (A) and human CES1 transfected: sc-111916 (B) 293T whole cell lysates.

CES1 (T-13) - sc-55922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CES1 (T-13): sc-55922. Western blot analysis of CES1 expression in non-transfected: sc-117752 (A) and human CES1 transfected: sc-111916 (B) 293T whole cell lysates.

Anti-Liver Carboxylesterase 1 antibody - ab45957 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Liver Carboxylesterase 1 antibody (ab45957) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate (ab7913)Lane 3 : Liver (Mouse) Tissue Lysate - normal tissueLane 4 : Liver (Rat) Tissue Lysate - normal tissueLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Liver Carboxylesterase 1 antibody - ab192409 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Liver Carboxylesterase 1 antibody - ab115280 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human Lung formalin-fixed, paraffin-embedded tissue stained with ab115280 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Liver Carboxylesterase 1 antibody - ab77730 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Liver Carboxylesterase 1 antibody (ab77730) at 0.03 µg/ml + Human Liver lysate (in RIPA buffer) at 35 µg

Anti-Liver Carboxylesterase 1 antibody - ab89779 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Liver Carboxylesterase 1 antibody (ab89779) at 1 µg/ml + human liver tissue lysate at 50 µg

Anti-Liver Carboxylesterase 1 antibody [EP1375Y] - ab68190 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1375Y
All lanes : Anti-Liver Carboxylesterase 1 antibody [EP1375Y] (ab68190) at 1/50000 dilutionLane 1 : U937 cell lysateLane 2 : human small intestine lysateLane 3 : human liver lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti-rabbit at 1/2000 dilution

Anti-Liver Carboxylesterase 1 antibody - C-terminal - ab180705 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Liver Carboxylesterase 1 antibody - C-terminal (ab180705) at 1/500 dilutionLane 1 : Mouse liver cell extractLane 2 : A549 cell extractLane 3 : U937 cell extract

Anti-Carboxylesterase 1 / CES1 Antibody - LS-C128076 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxylesterase 1 / CES1 Antibody (aa19-563, clone 11n45) - LS-C184202 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 11n45

Anti-Carboxylesterase 1 / CES1 Antibody - LS-C209230 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxylesterase 1 / CES1 Antibody (HRP) - LS-C209248 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxylesterase 1 / CES1 Antibody (Biotin) - LS-C209259 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxylesterase 1 / CES1 Antibody - LS-C306911 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-Carboxylesterase 1 / CES1 Antibody (C-Terminus, clone EP1375Y) - LS-C105283 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EP1375Y
Western blot analysis on (A) U937 (B) human small intestine (C) human liver lysate using anti-ACAT antibody (LS-C105283), dilution 1:50000.

Anti-Carboxylesterase 1 / CES1 Antibody (C-Terminus) - LS-C40351 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CES1 antibody LS-C40351 Western blot of PANC1 cell lysate.

Anti-Carboxylesterase 1 / CES1 Antibody (aa1-202) - LS-C311551 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Carboxylesterase 1 / CES1 Antibody - LS-C309886 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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