CES1

Gene Symbol CES1
Entrez Gene 1066
Alt Symbol ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
Species Human
Gene Type protein-coding
Description carboxylesterase 1
Other Description acyl coenzyme A:cholesterol acyltransferase|acyl-coenzyme A:cholesterol acyltransferase|brain carboxylesterase hBr1|carboxylesterase 1 (monocyte/macrophage serine esterase 1)|carboxylesterase 2 (liver)|cholesteryl ester hydrolase|cocaine carboxylesterase|egasyn|human monocyte/macrophage serine esterase 1|liver carboxylesterase 1|methylumbelliferyl-acetate deacetylase 1|monocyte/macrophage serine esterase|retinyl ester hydrolase|serine esterase 1|triacylglycerol hydrolase
Swissprots Q16788 Q16737 Q13657 Q00015 Q9ULY2 Q9UDG8 Q96EE8 Q9UK77 Q9UC52 P82127 Q86UK2 A8K3K8 A8K844 Q549X7 A6NIM1 E9PAU8 Q14062 P23141 Q549X8
Accessions BAA04650 BAC87750 BAC87751 BAE48735 BAE48737 BAE48738 BAE48739 BAE48740 CAA65527 EAW82838 EAW82839 EAW82840 P23141 AB025026 BAA84995 AB119995 BAC87748 AB119996 BAC87749 AF177775 AAD53175 AK290623 BAF83312 AK292209 BAF84898 AK301651 BAH13531 AU139632 AY268104 AAP20868 BC009706 BC012418 AAH12418 BC110338 AAI10339 CB137639 DQ891472 ABM82398 DQ894656 ABM85582 L07764 AAA16036 L07765 AAA35711 M55509 AAA35650 M65261 AAA83932 M73499 AAA35649 S73751 AAC60631 X52973 CAA37147 XM_005255774 XP_005255831 XM_005276867 XP_005276924 XM_011522816 XP_011521118 XM_011546995 XP_011545297 NM_001025194 NP_001020365 NM_001025195 NP_001020366 NM_001266 NP_001257
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. {ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000269|PubMed:10562416}.
Tissue Specificity Expressed predominantly in liver with lower levels in heart and lung. {ECO:0000269|PubMed:10562416}.
Top Pathways Drug metabolism - other enzymes

CES1 CRISPR/Cas9 KO Plasmid (h) - sc-405773 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 HDR Plasmid (h) - sc-405773-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 Double Nickase Plasmid (h) - sc-405773-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 Double Nickase Plasmid (h2) - sc-405773-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 CRISPR Activation Plasmid (h) - sc-405773-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 CRISPR Activation Plasmid (h2) - sc-405773-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 Lentiviral Activation Particles (h) - sc-405773-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 Lentiviral Activation Particles (h2) - sc-405773-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CES1 siRNA (h) - sc-62096 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CES1 shRNA Plasmid (h) - sc-62096-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CES1 shRNA (h) Lentiviral Particles - sc-62096-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CES2 RNAi - H00008824-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

CES2 RNAi - H00008824-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU106751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5983 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5983 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00284 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00284

CES1 siRNA (Human) - CRH0768 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CES1 - MBS8207183 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CES1(NM_001025194.1) - SHG135811 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CES1(NM_001025195.1) - SHG135847 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CES1(NM_001266.4) - SHG135883 from Creative biogene

Category siRNA
Species Reactivities Human

CES1 shRNA Plasmid (Human) - CHH0768 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CES1 miRNA 3'UTR clone - MiUTR1H-02064 from Creative biogene

Species Reactivities Human

CES1 miRNA 3'UTR clone - MiUTR1H-02065 from Creative biogene

Species Reactivities Human
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