CES1

Gene Symbol	CES1
Entrez Gene	1066
Alt Symbol	ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
Species	Human
Gene Type	protein-coding
Description	carboxylesterase 1
Other Description	acyl coenzyme A:cholesterol acyltransferase|acyl-coenzyme A:cholesterol acyltransferase|brain carboxylesterase hBr1|carboxylesterase 1 (monocyte/macrophage serine esterase 1)|carboxylesterase 2 (liver)|cholesteryl ester hydrolase|cocaine carboxylesterase|egasyn|human monocyte/macrophage serine esterase 1|liver carboxylesterase 1|methylumbelliferyl-acetate deacetylase 1|monocyte/macrophage serine esterase|retinyl ester hydrolase|serine esterase 1|triacylglycerol hydrolase
Swissprots	Q16788 Q16737 Q13657 Q00015 Q9ULY2 Q9UDG8 Q96EE8 Q9UK77 Q9UC52 P82127 Q86UK2 A8K3K8 A8K844 Q549X7 A6NIM1 E9PAU8 Q14062 P23141 Q549X8
Accessions	BAA04650 BAC87750 BAC87751 BAE48735 BAE48737 BAE48738 BAE48739 BAE48740 CAA65527 EAW82838 EAW82839 EAW82840 P23141 AB025026 BAA84995 AB119995 BAC87748 AB119996 BAC87749 AF177775 AAD53175 AK290623 BAF83312 AK292209 BAF84898 AK301651 BAH13531 AU139632 AY268104 AAP20868 BC009706 BC012418 AAH12418 BC110338 AAI10339 CB137639 DQ891472 ABM82398 DQ894656 ABM85582 L07764 AAA16036 L07765 AAA35711 M55509 AAA35650 M65261 AAA83932 M73499 AAA35649 S73751 AAC60631 X52973 CAA37147 XM_005255774 XP_005255831 XM_005276867 XP_005276924 XM_011522816 XP_011521118 XM_011546995 XP_011545297 NM_001025194 NP_001020365 NM_001025195 NP_001020366 NM_001266 NP_001257
Function	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. {ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443}.
Subcellular Location	Endoplasmic reticulum lumen {ECO:0000269|PubMed:10562416}.
Tissue Specificity	Expressed predominantly in liver with lower levels in heart and lung. {ECO:0000269|PubMed:10562416}.
Top Pathways	Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CES1-Over-expression-Lysate - LY12375a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CES1 293T Cell Transient Overexpression Lysate(Denatured) - H00001066-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CES1 overexpression lysate - LY400509 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CES1 overexpression lysate - LY422599 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CES1 overexpression lysate - LY422600 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CES1 293 Cell Lysate - 400514 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CES1 293 Cell Lysate - 409762 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CES1 Overexpression Lysate (Denatured) - H00001066-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CES1 Overexpression Lysate (Native) - NBL1-09113 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CES1 Overexpression Lysate (Native) - NBL1-09112 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CES1 (h): 293T Lysate - sc-111916 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CES1 Over-expression Lysate Product - GWB-3F934A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CES1 Over-expression Lysate Product - GWB-3BCE65 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human CES2 / Carboxylesterase-2 HEK293 Cell Lysate (WB positive control) - 10380-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CES2 Human Cells Transfected Lysate (positive control) (denatured) - orb173611 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human CES1 Knockdown Stable Cell Line - CSC-DC003019 from Creative biogene Category Cell Line Species Human

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