CES1

Gene Symbol	CES1
Entrez Gene	1066
Alt Symbol	ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
Species	Human
Gene Type	protein-coding
Description	carboxylesterase 1
Other Description	acyl coenzyme A:cholesterol acyltransferase|acyl-coenzyme A:cholesterol acyltransferase|brain carboxylesterase hBr1|carboxylesterase 1 (monocyte/macrophage serine esterase 1)|carboxylesterase 2 (liver)|cholesteryl ester hydrolase|cocaine carboxylesterase|egasyn|human monocyte/macrophage serine esterase 1|liver carboxylesterase 1|methylumbelliferyl-acetate deacetylase 1|monocyte/macrophage serine esterase|retinyl ester hydrolase|serine esterase 1|triacylglycerol hydrolase
Swissprots	Q16788 Q16737 Q13657 Q00015 Q9ULY2 Q9UDG8 Q96EE8 Q9UK77 Q9UC52 P82127 Q86UK2 A8K3K8 A8K844 Q549X7 A6NIM1 E9PAU8 Q14062 P23141 Q549X8
Accessions	BAA04650 BAC87750 BAC87751 BAE48735 BAE48737 BAE48738 BAE48739 BAE48740 CAA65527 EAW82838 EAW82839 EAW82840 P23141 AB025026 BAA84995 AB119995 BAC87748 AB119996 BAC87749 AF177775 AAD53175 AK290623 BAF83312 AK292209 BAF84898 AK301651 BAH13531 AU139632 AY268104 AAP20868 BC009706 BC012418 AAH12418 BC110338 AAI10339 CB137639 DQ891472 ABM82398 DQ894656 ABM85582 L07764 AAA16036 L07765 AAA35711 M55509 AAA35650 M65261 AAA83932 M73499 AAA35649 S73751 AAC60631 X52973 CAA37147 XM_005255774 XP_005255831 XM_005276867 XP_005276924 XM_011522816 XP_011521118 XM_011546995 XP_011545297 NM_001025194 NP_001020365 NM_001025195 NP_001020366 NM_001266 NP_001257
Function	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. {ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443}.
Subcellular Location	Endoplasmic reticulum lumen {ECO:0000269|PubMed:10562416}.
Tissue Specificity	Expressed predominantly in liver with lower levels in heart and lung. {ECO:0000269|PubMed:10562416}.
Top Pathways	Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Liver Carboxylesterase 1 full length protein - ab114347 from Abcam Category Protein Source Wheat germ Species Human

Human Liver Carboxylesterase 1 peptide - ab66527 from Abcam Category Peptide

Human Liver Carboxylesterase 1 protein fragment - ab151864 from Abcam Category Protein Source HEK 293 cells Species Human

CES2 / Esterase Antibody Blocking Peptide - LS-E384 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CES2 / Esterase Antibody Blocking Peptide - LS-E15735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Carboxylesterase 1 / CES1 Antibody Blocking Peptide - LS-E26652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Carboxylesterase 1 / CES1 Antibody Blocking Peptide - LS-E15411 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CES2 Protein - H00008824-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CES2 Protein - H00008824-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CES1 Protein - H00001066-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CES1 blocking peptide - GTX88792-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

SCRN1 Peptide - GTX85172-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human Carboxylesterase 1/CES1, CF - 4920-CE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, His19-Glu563, with a C-terminal 10-His tag

CES1 Protein Lysate (APL10380) - APL10380 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

CES1 Protein Lysate (APL10381) - APL10381 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

CES1 Protein Lysate (APL10382) - APL10382 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human CES1 protein - orb49243 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Carboxylesterase 1 Blocking Peptide - 33R-9660 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Carboxylesterase 1 Blocking Peptide - 33R-1397 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CES2 Blocking Peptide - abx063519 from Abbexa Category Peptide Species Human, Mouse, Rat

Liver Carboxylesterase 1 Peptide - AC21-1488-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CES1 / ACAT - H00001066-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CES1 / ACAT - H00001066-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Carboxylesterase 1, CES1, Human, Recombinant - 19-C450 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source HEK293 Species Human

CES1 Peptide - 46-640P from ProSci Category Peptide Species Human

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