| Gene Symbol | EPHB3 |
|---|---|
| Entrez Gene | 2049 |
| Alt Symbol | ETK2, HEK2, TYRO6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor B3 |
| Other Description | EK2|EPH-like kinase 2|EPH-like tyrosine kinase 2|EPH-like tyrosine kinase-2|embryonic kinase 2|ephrin type-B receptor 3|human embryo kinase 2|tyrosine-protein kinase TYRO6 |
| Swissprots | Q7Z740 P54753 |
| Accessions | CAT16951 EAW78236 EAW78237 P54753 BC052968 AAH52968 CB993133 X75208 CAA53021 NM_004443 NP_004434 |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15536074}; Single-pass type I membrane protein {ECO:0000269|PubMed:15536074}. Cell projection, dendrite {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Axon guidance |