EPHB3

Gene Symbol	EPHB3
Entrez Gene	2049
Alt Symbol	ETK2, HEK2, TYRO6
Species	Human
Gene Type	protein-coding
Description	EPH receptor B3
Other Description	EK2|EPH-like kinase 2|EPH-like tyrosine kinase 2|EPH-like tyrosine kinase-2|embryonic kinase 2|ephrin type-B receptor 3|human embryo kinase 2|tyrosine-protein kinase TYRO6
Swissprots	Q7Z740 P54753
Accessions	CAT16951 EAW78236 EAW78237 P54753 BC052968 AAH52968 CB993133 X75208 CAA53021 NM_004443 NP_004434
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis,
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15536074}; Single-pass type I membrane protein {ECO:0000269|PubMed:15536074}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Eph receptor B3 protein fragment - ab51409 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Eph receptor B3 full length protein - ab132962 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor B3 protein fragment - ab158376 from Abcam Category Protein Source Wheat germ Species Human

EPHB3 / EPH Receptor B3 Antibody Blocking Peptide - LS-E9116 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHB3 / EPH Receptor B3 Antibody Blocking Peptide - LS-E23275 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EphB3 Recombinant Protein - H00002049-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EphB3 Partial Recombinant Protein - H00002049-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EphB3 Recombinant Protein - P3859 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

EphB3 Recombinant Protein - P4684 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Mouse-Ephb3-Antibody-Center-Blocking-Peptide - BP14819c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

Recombinant Human EphB3 Fc Chimera, CF - 5667-B3-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu38-Ala550

Human EphB3 protein (GST Tag) - orb138788 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

EPHB3 (phospho-Tyr608) Blocking Peptide - abx064152 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Pig

EPHB3 Blocking Peptide - abx064153 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Pig

EPHB3 - H00002049-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EPHB3 - H00002049-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EPHB3 - H00002049-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHB3 - H00002049-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHB3 - P3859 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

EPHB3 - P4684 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

EPHB3 Control Peptide - AP10024CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

EPHB3 fusion protein - ag5579 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

EPHB3 fusion protein - ag17050 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

EPHB3 fusion protein - Ag16016 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EPH Receptor B3, GST-tagged, Active - EPHB3-305H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

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