Gene Symbol | ENTPD4 |
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Entrez Gene | 9583 |
Alt Symbol | LALP70, LAP70, LYSAL1, NTPDase-4, UDPase |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleoside triphosphate diphosphohydrolase 4 |
Other Description | golgi luminal UDPase|guanosine-diphosphatase like protein|lysosomal apyrase-like 1|lysosomal apyrase-like protein of 70 kDa|uridine-diphosphatase |
Swissprots | O15092 D3DSS3 Q9Y227 |
Accessions | CAB45655 EAW63621 EAW63622 EAW63623 Q9Y227 AB002390 BAA21575 AF016032 AAC17217 AJ131358 CAB40415 AK300464 BAG62183 BC034477 AAH34477 CN313713 CN313716 DB091432 DB153397 DC341200 DQ890824 ABM81750 DQ893978 ABM84904 NM_001128930 NP_001122402 NM_004901 NP_004892 |
Function | Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes. |
Tissue Specificity | Ubiquitous. Highest expression in testis and lowest in bladder. |
Top Pathways | Lysosome, Purine metabolism, Pyrimidine metabolism |
LALP70 (E-18) - sc-87191 from Santa Cruz Biotechnology
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Anti-ENTPD4 antibody - ab128577 from Abcam
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Anti-ENTPD4 antibody - ab69896 from Abcam
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Anti-ENTPD4 antibody - N-terminal - ab173978 from Abcam
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Anti-ENTPD4 / LALP70 Antibody (aa40-69, Azide-free, HRP) - LS-C222417 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa40-69, APC) - LS-C222413 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa40-69, FITC) - LS-C222416 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa40-69, Biotin) - LS-C222415 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa40-69, AP) - LS-C222412 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa40-69, PE) - LS-C222418 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody - LS-C307926 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa371-469) - LS-C307927 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa39-69) - LS-C321123 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody (aa40-69) - LS-C159534 from LifeSpan Bioscience
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Anti-ENTPD4 / LALP70 Antibody - LS-C332514 from LifeSpan Bioscience
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ENTPD4 Antibody - NBP1-81510 from Novus Biologicals
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ENTPD4 Antibody (4H7) - H00009583-M01 from Novus Biologicals
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ENTPD4 Antibody - H00009583-B01P from Novus Biologicals
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ENTPD4 Antibody - H00009583-B01 from Novus Biologicals
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Anti-ENTPD4 antibody produced in mouse - SAB1406851 from Sigma-Aldrich
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Monoclonal Anti-ENTPD4 antibody produced in mouse - SAB1402477 from Sigma-Aldrich
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ENTPD4-Antibody-N-term - AP18180a from Abgent, a WuXi AppTec company
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ENTPD4 Antibody - N-terminal region (OAAB13678) - OAAB13678 from Aviva Systems Biology
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ENTPD4 antibody - orb78294 from Biorbyt
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ENTPD4 antibody - 70R-36204 from Fitzgerald
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