| Gene Symbol |
ENTPD4
|
| Entrez Gene |
9583
|
| Alt Symbol |
LALP70, LAP70, LYSAL1, NTPDase-4, UDPase
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ectonucleoside triphosphate diphosphohydrolase 4
|
| Other Description |
golgi luminal UDPase|guanosine-diphosphatase like protein|lysosomal apyrase-like 1|lysosomal apyrase-like protein of 70 kDa|uridine-diphosphatase
|
| Swissprots |
O15092 D3DSS3 Q9Y227
|
| Accessions |
CAB45655 EAW63621 EAW63622 EAW63623 Q9Y227 AB002390 BAA21575 AF016032 AAC17217 AJ131358 CAB40415 AK300464 BAG62183 BC034477 AAH34477 CN313713 CN313716 DB091432 DB153397 DC341200 DQ890824 ABM81750 DQ893978 ABM84904 NM_001128930 NP_001122402 NM_004901 NP_004892
|
| Function |
Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes.
|
| Tissue Specificity |
Ubiquitous. Highest expression in testis and lowest in bladder.
|
| Top Pathways |
Lysosome, Purine metabolism, Pyrimidine metabolism
|