ENTPD4

Gene Symbol	ENTPD4
Entrez Gene	9583
Alt Symbol	LALP70, LAP70, LYSAL1, NTPDase-4, UDPase
Species	Human
Gene Type	protein-coding
Description	ectonucleoside triphosphate diphosphohydrolase 4
Other Description	golgi luminal UDPase|guanosine-diphosphatase like protein|lysosomal apyrase-like 1|lysosomal apyrase-like protein of 70 kDa|uridine-diphosphatase
Swissprots	O15092 D3DSS3 Q9Y227
Accessions	CAB45655 EAW63621 EAW63622 EAW63623 Q9Y227 AB002390 BAA21575 AF016032 AAC17217 AJ131358 CAB40415 AK300464 BAG62183 BC034477 AAH34477 CN313713 CN313716 DB091432 DB153397 DC341200 DQ890824 ABM81750 DQ893978 ABM84904 NM_001128930 NP_001122402 NM_004901 NP_004892
Function	Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.
Subcellular Location	Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes.
Tissue Specificity	Ubiquitous. Highest expression in testis and lowest in bladder.
Top Pathways	Lysosome, Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LALP70 CRISPR/Cas9 KO Plasmid (h) - sc-411298 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 HDR Plasmid (h) - sc-411298-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 Double Nickase Plasmid (h) - sc-411298-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 Double Nickase Plasmid (h2) - sc-411298-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 CRISPR Activation Plasmid (h) - sc-411298-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 CRISPR Activation Plasmid (h2) - sc-411298-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 Lentiviral Activation Particles (h) - sc-411298-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 Lentiviral Activation Particles (h2) - sc-411298-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LALP70 siRNA (h) - sc-77816 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LALP70 shRNA Plasmid (h) - sc-77816-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LALP70 shRNA (h) Lentiviral Particles - sc-77816-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ENTPD4 RNAi - H00009583-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU062151 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU001361 from Sigma-Aldrich Category siRNA

MISSION® Human Phosphatase - SIHP0191 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0190 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0192 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN7892 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7892 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02329 from Sigma-Aldrich Category miRNA

ENTPD4 siRNA (Human) - CRH6377 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ENTPD4 - MBS8213350 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ENTPD4 (NM_004901.4) - SHH286061 from Creative biogene Category siRNA Species Reactivities Human

Human ENTPD4 siRNA - orb266879 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ENTPD4 shRNA Plasmid (Human) - CHH6377 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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