| Gene Symbol |
UBA7
|
| Entrez Gene |
7318
|
| Alt Symbol |
D8, UBA1B, UBE1L, UBE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-like modifier activating enzyme 7
|
| Other Description |
UBA1, ubiquitin-activating enzyme E1 homolog B|UBA7, ubiquitin-activating enzyme E1|ubiquitin-activating enzyme 7|ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme E1-related protein|ubiquitin-activating enzyme-2|ubiquitin-like modifier-activating enzyme 7
|
| Swissprots |
P41226 Q9BRB2
|
| Accessions |
AAG49557 EAW65023 EAW65024 P41226 BC006378 AAH06378 BM152341 BT007026 AAP35672 CA425139 DQ893307 ABM84233 DQ893707 ABM84633 L13852 AAA75388 XM_005265430 XP_005265487 XM_006713321 XP_006713384 XM_011534070 XP_011532372 XM_011534071 XP_011532373 XM_011534072 XP_011532374 XM_011534073 XP_011532375 NM_003335 NP_003326
|
| Function |
Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:20133869}.
|
| Tissue Specificity |
Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|