UBA7

Gene Symbol UBA7
Entrez Gene 7318
Alt Symbol D8, UBA1B, UBE1L, UBE2
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 7
Other Description UBA1, ubiquitin-activating enzyme E1 homolog B|UBA7, ubiquitin-activating enzyme E1|ubiquitin-activating enzyme 7|ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme E1-related protein|ubiquitin-activating enzyme-2|ubiquitin-like modifier-activating enzyme 7
Swissprots P41226 Q9BRB2
Accessions AAG49557 EAW65023 EAW65024 P41226 BC006378 AAH06378 BM152341 BT007026 AAP35672 CA425139 DQ893307 ABM84233 DQ893707 ABM84633 L13852 AAA75388 XM_005265430 XP_005265487 XM_006713321 XP_006713384 XM_011534070 XP_011532372 XM_011534071 XP_011532373 XM_011534072 XP_011532374 XM_011534073 XP_011532375 NM_003335 NP_003326
Function Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:20133869}.
Tissue Specificity Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
Top Pathways Ubiquitin mediated proteolysis

UBE1L (B-7) - sc-390097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE1L (B-7): sc-390097. Western blot analysis of UBE1L expression in HL-60 (A) and I-11.15 (B) whole cell lysates.

UBE1L (G-11) - sc-390238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE1L (G-11): sc-390238. Western blot analysis of UBE1L expression in HL-60 whole cell lysate.

UBE1L (H-208) - sc-135079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
UBE1L (H-208): sc-135079. Western blot analysis of UBE1L expression in HL-60 (A), Hep G2 (B), Jurkat (C), RT-4 (D), A-431 (E) and THP-1 (F) whole cell lysates.

UBE1L (P-20) - sc-54439 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE1L (P-20): sc-54439. Western blot analysis of UBE1L expression in HL-60 whole cell lysate.

UBE1L (M-204) - sc-135078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
UBE1L (M-204): sc-135078. Western blot analysis of UBE1L expression in I-11.15 whole cell lysate.

UBE1L (S-18) - sc-54440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE1L (S-18): sc-54440. Western blot analysis of UBE1L expression in HL-60 whole cell lysate.

Anti-Ube1L antibody - ab12199 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry using ab12200 (C-terminus) and ab12199 (N-terminus) with peptide blocking (right panel) and without peptide blocking (left panel).

Anti-Ube1L antibody - ab12200 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry using ab12200 (C-terminus) and ab12199 (N-terminus) with peptide blocking (right panel) and without peptide blocking (left panel).

Anti-Ube1L antibody - ab89647 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Ube1L antibody (ab89647) at 1 µg/ml + Human liver tissue lysate at 50 µg

Anti-Ube1L antibody - ab58452 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ube1L antibody (ab58452) at 1/500 dilutionLane 1 : extracts from HeLa cellsLane 2 : extracts from HeLa cells with immunizing peptide

Anti-Ube1L antibody [EPR4269(2)] - ab133479 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4269(2)
Overlay histogram showing HeLa cells stained with ab133479 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab133479, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Ube1L antibody [EPR4270] - ab108929 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4270
All lanes : Anti-Ube1L antibody [EPR4270] (ab108929) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : HL60 cell lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysateLane 5 : Fetal liver lysateLysates/proteins at 10 µg per lane.

Anti-Ube1L antibody - Azide free - ab167663 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Ube1L antibody - Azide free (ab167663) at 1/500 dilutionLane 1 : Ube1L transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilutiondeveloped using the ECL technique

Anti-UBE1L / UBA7 Antibody (aa222-240) - LS-C10939 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (N-Terminus) - LS-C189281 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa239-268, AP) - LS-C272831 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa239-268, APC) - LS-C272832 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa239-268, Biotin) - LS-C272833 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa239-268, FITC) - LS-C272834 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa239-268, Azide-free, HRP) - LS-C272835 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa239-268, PE) - LS-C272837 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody - LS-C314680 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa238-268) - LS-C326125 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L / UBA7 Antibody (aa249-517) - LS-C314682 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant UBE1L / UBA7.

Anti-UBE1L / UBA7 Antibody (aa23-238) - LS-C314681 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant UBE1L / UBA7.
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