Gene Symbol | UBA7 |
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Entrez Gene | 7318 |
Alt Symbol | D8, UBA1B, UBE1L, UBE2 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-like modifier activating enzyme 7 |
Other Description | UBA1, ubiquitin-activating enzyme E1 homolog B|UBA7, ubiquitin-activating enzyme E1|ubiquitin-activating enzyme 7|ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme E1-related protein|ubiquitin-activating enzyme-2|ubiquitin-like modifier-activating enzyme 7 |
Swissprots | P41226 Q9BRB2 |
Accessions | AAG49557 EAW65023 EAW65024 P41226 BC006378 AAH06378 BM152341 BT007026 AAP35672 CA425139 DQ893307 ABM84233 DQ893707 ABM84633 L13852 AAA75388 XM_005265430 XP_005265487 XM_006713321 XP_006713384 XM_011534070 XP_011532372 XM_011534071 XP_011532373 XM_011534072 XP_011532374 XM_011534073 XP_011532375 NM_003335 NP_003326 |
Function | Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:20133869}. |
Tissue Specificity | Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines. |
Top Pathways | Ubiquitin mediated proteolysis |
UBE1L CRISPR/Cas9 KO Plasmid (h) - sc-407386 from Santa Cruz Biotechnology
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UBE1L HDR Plasmid (h) - sc-407386-HDR from Santa Cruz Biotechnology
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UBE1L Double Nickase Plasmid (h) - sc-407386-NIC from Santa Cruz Biotechnology
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UBE1L Double Nickase Plasmid (h2) - sc-407386-NIC-2 from Santa Cruz Biotechnology
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UBE1L CRISPR Activation Plasmid (h) - sc-407386-ACT from Santa Cruz Biotechnology
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UBE1L CRISPR Activation Plasmid (h2) - sc-407386-ACT-2 from Santa Cruz Biotechnology
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UBE1L Lentiviral Activation Particles (h) - sc-407386-LAC from Santa Cruz Biotechnology
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UBE1L Lentiviral Activation Particles (h2) - sc-407386-LAC-2 from Santa Cruz Biotechnology
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UBE1L siRNA (h) - sc-106657 from Santa Cruz Biotechnology
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UBE1L shRNA Plasmid (h) - sc-106657-SH from Santa Cruz Biotechnology
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UBE1L shRNA (h) Lentiviral Particles - sc-106657-V from Santa Cruz Biotechnology
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ISG15 Activating Enzyme/UBE1L RNAi - H00007318-R01 from Novus Biologicals
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MISSION® esiRNA - EHU134271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22342 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22342 from Sigma-Aldrich
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UBA7 siRNA (Human) - CRH5001 from Cohesion Biosciences
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UBA7 - MBS8211711 from MyBioSource |
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shRNA set against Human UBA7 (NM_003335.2) - SHH438708 from Creative biogene
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Human UBA7 siRNA - orb265503 from Biorbyt
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UBA7 shRNA Plasmid (Human) - CHH5001 from Cohesion Biosciences
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UBA7 miRNA 3'UTR clone - MiUTR1H-10931 from Creative biogene
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