Gene Symbol | SAE1 |
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Entrez Gene | 10055 |
Alt Symbol | AOS1, HSPC140, SUA1, UBLE1A |
Species | Human |
Gene Type | protein-coding |
Description | SUMO1 activating enzyme subunit 1 |
Other Description | SUMO-1 activating enzyme E1 N subunit|SUMO-1 activating enzyme subunit 1|SUMO-activating enzyme subunit 1|activator of SUMO1|sentrin/SUMO-activating protein AOS1|ubiquitin-like 1-activating enzyme E1A|ubiquitin-like protein SUMO-1 activating enzyme |
Swissprots | G3XAK6 Q9UBE0 O95717 B2RDP5 Q9P020 F5GXX7 B3KMQ2 |
Accessions | EAW57460 EAW57461 EAW57462 EAW57463 EAW57464 Q9UBE0 AF046025 AAD23902 AF090385 AAD12785 AF110956 AAD24433 AF161489 AAF29104 AI339364 AK021978 BAG51064 AK027595 BAG51356 AK055481 AK090645 AK302287 BAG63628 AK315624 BAG37992 BC000344 AAH00344 BC003611 AAH03611 BC018271 AAH18271 BC128518 BC128519 BT007290 AAP35954 CN386158 DA047601 DA086973 DC297573 DC312737 DQ891751 ABM82677 DQ894932 ABM85858 XM_006722963 XP_006723026 XM_006722965 XP_006723028 XM_011526305 XP_011524607 NM_001145713 NP_001139185 NM_001145714 NP_001139186 NM_005500 NP_005491 NR_027280 |
Function | The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11481243}. |
Tissue Specificity | Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}. |
Top Pathways | Ubiquitin mediated proteolysis |
UBLE1A/SAE1 Antibody - 13585 from Cell Signaling Technology
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AOS-1 (H-9) - sc-398080 from Santa Cruz Biotechnology
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AOS-1 (C-14) - sc-46763 from Santa Cruz Biotechnology
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AOS-1 (C-15) - sc-46764 from Santa Cruz Biotechnology
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AOS-1 (E-12) - sc-376628 from Santa Cruz Biotechnology
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AOS-1 (G-3) - sc-376146 from Santa Cruz Biotechnology
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AOS-1 (H-7) - sc-271592 from Santa Cruz Biotechnology
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AOS-1 (N-14) - sc-46765 from Santa Cruz Biotechnology
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AOS-1 (N-18) - sc-46766 from Santa Cruz Biotechnology
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Anti-SAE1 antibody [1G8] - ab140964 from Abcam
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Anti-SAE1 antibody [2946C4a] - ab71959 from Abcam
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Anti-SAE1 antibody [EPR15397(B)] - ab185949 from Abcam
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Anti-SAE1 antibody [EPR15398] - ab185552 from Abcam
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Anti-SAE1 antibody - ab58383 from Abcam
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Anti-SAE1 antibody - ab38434 from Abcam
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Anti-SAE1 antibody - ab56957 from Abcam
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Anti-SAE1 antibody - ab5645 from Abcam
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Anti-SAE1 Antibody (clone 6C7) - LS-C339476 from LifeSpan Bioscience
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Anti-SAE1 Antibody (clone 3C3) - LS-C339550 from LifeSpan Bioscience
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Anti-SAE1 Antibody (clone 6B11) - LS-C339477 from LifeSpan Bioscience
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Anti-SAE1 Antibody - LS-C17948 from LifeSpan Bioscience
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Anti-SAE1 Antibody - LS-C76152 from LifeSpan Bioscience
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Anti-SAE1 Antibody - LS-C122457 from LifeSpan Bioscience
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Anti-SAE1 Antibody - LS-C132310 from LifeSpan Bioscience
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Anti-SAE1 Antibody - LS-C147913 from LifeSpan Bioscience
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