CEMIP

Gene Symbol	CEMIP
Entrez Gene	57214
Alt Symbol	CCSP1, KIAA1199, TMEM2L
Species	Human
Gene Type	protein-coding
Description	cell migration inducing protein, hyaluronan binding
Other Description	cell migration-inducing and hyaluronan-binding protein|colon cancer secreted protein 1
Swissprots	Q9NPN9 Q9ULM1 Q9H1K5 Q8WUJ3 Q6L9J5
Accessions	CDI30208 EAW99111 Q8WUJ3 AB033025 BAA86513 AB103330 BAD02451 AK000465 AK026540 AK027058 AL049389 AL109718 AL359061 CAB94391 AY007811 AAG41059 AY581148 AAU06219 AY581149 AAU06220 AY585237 AAU06221 BC020256 AAH20256 DA220969 NM_001293298 NP_001280227 NM_001293304 NP_001280233 NM_018689 NP_061159
Function	Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.
Subcellular Location	Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP- dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Tissue Specificity	Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:12471561, ECO:0000269|PubMed:16157444, ECO:0000269|PubMed:19434458, ECO:0000269|PubMed:21772334, ECO:0000269|PubMed:22970280, ECO:0000269|PubMed:23936024, ECO:0000269|PubMed:23990668}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CEMIP / KIAA1199 ELISA Kit (Sandwich ELISA) - LS-F7390 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

KIAA1199, Human, ELISA Kit - CSB-E13092h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.2 ng/ml Range 1 ng/ml-24 ng/ml

Transmembrane Protein 2 Like Protein (TMEM2L), Human, ELISA Kit - SER965Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.052ng/mL Range 0.156-10ng/mL

KIAA1199 (Human) IP-WB Antibody Pair - H00057214-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

KIAA1199 (Human) IP-WB Antibody Pair - H00057214-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

KIAA1199, ELISA Kit - MBS701499 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.2 ng/ml Range 1 ng/ml-24 ng/ml

ELISA Kit for Transmembrane Protein 2 Like Protein (TMEM2L) - SER965Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human KIAA1199 ELISA Kit - CSB-E13092h from Cusabio Category ELISA Kit Sensitivity 0.4 ng/ml Range 1 ng/ml-24 ng/ml

ELISA Kit for Transmembrane Protein 2 Like Protein (TMEM2L) - SER965Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human TMEM2L ELISA Kit - abx153315 from Abbexa Category ELISA Kit Sensitivity 0.052 ng/ml Range 0.156 ng/ml - 10 ng/ml

Transmembrane Protein 2 Like Protein (TMEM2L), Human, ELISA Kit - DL-TMEM2L-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human TMEM2L ELISA Kit - abx571053 from Abbexa Category ELISA Kit Sensitivity 0.052 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human KIAA1199 ELISA Kit - EKC34350 from Biomatik Category ELISA Kit Prices $795.00, $3,021.00, $5,644.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.4 ng/ml Range 1 ng/ml-24 ng/ml

Human KIAA1199 ELISA Kit - E021697 from Biobool Category ELISA Kit Sensitivity 0.2 ng/ml

Human TMEM2L ELISA Kit - E039268 from Biobool Category ELISA Kit Sensitivity Typically less than 0.055ng/mL.

Human CEMIP ELISA Kit - E078315 from Biobool Category ELISA Kit

TMEM2L ELISA Kit (Human) (OKDD00566) - OKDD00566 from Aviva Systems Biology Category ELISA Kit Prices $620.00 Sizes 96 wells Sensitivity < 0.052 ng/mL Range 0.156-10 ng/mL

Transmembrane Protein 2 Like Protein (TMEM2L), ELISA Kit - MBS451139 from MyBioSource Category ELISA Kit Prices $445.00, $590.00, $2,620.00, $5,095.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.052ng/mL Range 0.156-10ng/mL

Human KIAA1199 ELISA Kit - EKC40932 from Biomatik Category ELISA Kit Prices $790.00 Sizes 96 tests Sensitivity 0.4 ng/mL Range 1 ng/mL-24 ng/mL

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