| Gene Symbol |
CEMIP
|
| Entrez Gene |
57214
|
| Alt Symbol |
CCSP1, KIAA1199, TMEM2L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell migration inducing protein, hyaluronan binding
|
| Other Description |
cell migration-inducing and hyaluronan-binding protein|colon cancer secreted protein 1
|
| Swissprots |
Q9NPN9 Q9ULM1 Q9H1K5 Q8WUJ3 Q6L9J5
|
| Accessions |
CDI30208 EAW99111 Q8WUJ3 AB033025 BAA86513 AB103330 BAD02451 AK000465 AK026540 AK027058 AL049389 AL109718 AL359061 CAB94391 AY007811 AAG41059 AY581148 AAU06219 AY581149 AAU06220 AY585237 AAU06221 BC020256 AAH20256 DA220969 NM_001293298 NP_001280227 NM_001293304 NP_001280233 NM_018689 NP_061159
|
| Function |
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP- dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
|
| Tissue Specificity |
Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:12471561, ECO:0000269|PubMed:16157444, ECO:0000269|PubMed:19434458, ECO:0000269|PubMed:21772334, ECO:0000269|PubMed:22970280, ECO:0000269|PubMed:23936024, ECO:0000269|PubMed:23990668}.
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