CEMIP

Gene Symbol CEMIP
Entrez Gene 57214
Alt Symbol CCSP1, KIAA1199, TMEM2L
Species Human
Gene Type protein-coding
Description cell migration inducing protein, hyaluronan binding
Other Description cell migration-inducing and hyaluronan-binding protein|colon cancer secreted protein 1
Swissprots Q9NPN9 Q9ULM1 Q9H1K5 Q8WUJ3 Q6L9J5
Accessions CDI30208 EAW99111 Q8WUJ3 AB033025 BAA86513 AB103330 BAD02451 AK000465 AK026540 AK027058 AL049389 AL109718 AL359061 CAB94391 AY007811 AAG41059 AY581148 AAU06219 AY581149 AAU06220 AY585237 AAU06221 BC020256 AAH20256 DA220969 NM_001293298 NP_001280227 NM_001293304 NP_001280233 NM_018689 NP_061159
Function Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.
Subcellular Location Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP- dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Tissue Specificity Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:12471561, ECO:0000269|PubMed:16157444, ECO:0000269|PubMed:19434458, ECO:0000269|PubMed:21772334, ECO:0000269|PubMed:22970280, ECO:0000269|PubMed:23936024, ECO:0000269|PubMed:23990668}.

KIAA1199 CRISPR/Cas9 KO Plasmid (h) - sc-412779 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 HDR Plasmid (h) - sc-412779-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 Double Nickase Plasmid (h) - sc-412779-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 Double Nickase Plasmid (h2) - sc-412779-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 CRISPR Activation Plasmid (h) - sc-412779-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 CRISPR Activation Plasmid (h2) - sc-412779-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 Lentiviral Activation Particles (h) - sc-412779-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 Lentiviral Activation Particles (h2) - sc-412779-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1199 siRNA (h) - sc-90061 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIAA1199 shRNA Plasmid (h) - sc-90061-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIAA1199 shRNA (h) Lentiviral Particles - sc-90061-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU068761 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11110 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11110 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12954 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12954

CEMIP siRNA (Human) - CRJ1399 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CEMIP - MBS8233167 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KIAA1199 (NM_018689.1) - SHH324699 from Creative biogene

Category siRNA
Species Reactivities Human

Human CEMIP siRNA - orb271900 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CEMIP shRNA Plasmid (Human) - CHJ1399 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KIAA1199 miRNA 3'UTR clone - MiUTR1H-05252 from Creative biogene

Species Reactivities Human
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