CEMIP

Gene Symbol	CEMIP
Entrez Gene	57214
Alt Symbol	CCSP1, KIAA1199, TMEM2L
Species	Human
Gene Type	protein-coding
Description	cell migration inducing protein, hyaluronan binding
Other Description	cell migration-inducing and hyaluronan-binding protein\|colon cancer secreted protein 1
Swissprots	Q9NPN9 Q9ULM1 Q9H1K5 Q8WUJ3 Q6L9J5
Accessions	CDI30208 EAW99111 Q8WUJ3 AB033025 BAA86513 AB103330 BAD02451 AK000465 AK026540 AK027058 AL049389 AL109718 AL359061 CAB94391 AY007811 AAG41059 AY581148 AAU06219 AY581149 AAU06220 AY585237 AAU06221 BC020256 AAH20256 DA220969 NM_001293298 NP_001280227 NM_001293304 NP_001280233 NM_018689 NP_061159
Function	Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. {ECO:0000269\|PubMed:23509262, ECO:0000269\|PubMed:23990668, ECO:0000269\|PubMed:24269685}.
Subcellular Location	Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP- dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Tissue Specificity	Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue. {ECO:0000269\|PubMed:10574462, ECO:0000269\|PubMed:12471561, ECO:0000269\|PubMed:16157444, ECO:0000269\|PubMed:19434458, ECO:0000269\|PubMed:21772334, ECO:0000269\|PubMed:22970280, ECO:0000269\|PubMed:23936024, ECO:0000269\|PubMed:23990668}.

KIAA1199 (E-14) - sc-164775 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KIAA1199 (E-14): sc-164775. Western blot analysis of KIAA1199 expression in BE (2)-M17 whole cell lysate.

Anti-KIAA1199 antibody - ab76849 from Abcam

Prices	$387.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-KIAA1199 antibody (ab76849) at 5 µg/ml + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilutiondeveloped using the ECL technique

Anti-KIAA1199 antibody - ab107073 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIAA1199 antibody (ab107073) at 1/100 dilution + Mouse spleen tissue lysates at 35 µg

Anti-KIAA1199 antibody - ab98947 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KIAA1199 antibody (ab98947) at 1 µg/ml + COLO205 cell lysate at 10 µg

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321, AP) - LS-C260771 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321, APC) - LS-C260772 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321, Biotin) - LS-C260773 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321, FITC) - LS-C260774 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321, Azide-free, HRP) - LS-C260775 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody - LS-C308626 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa880-980) - LS-C308627 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321, PE) - LS-C260776 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody - LS-C311315 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321) - LS-C165387 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

K1199 Antibody western blot of mouse spleen tissue lysates (35 ug/lane). The K1199 antibody detected the K1199 protein (arrow).

Anti-CEMIP / KIAA1199 Antibody - LS-C311317 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa1292-1321) - LS-C329709 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CEMIP / KIAA1199 Antibody (aa755-804) - LS-C108052 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KIAA1199 antibody LS-C108052 Western blot of COLO205 cell lysate.

KIAA1199 Antibody - NBP1-58029 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: KIAA1199 Antibody [NBP1-58029] - Sample Tissue: Human OVCAR-3 Antibody Dilution: 1.0 ug/ml

KIAA1199 Antibody - 45750002 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

KIAA1199 Antibody - NBP1-83096 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: KIAA1199 Antibody [NBP1-83096] - Staining of human stomach, upper shows moderate cytoplasmic positivity in glandular cells.

KIAA1199 Antibody - NBP1-83095 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: KIAA1199 Antibody [NBP1-83095] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells.

KIAA1199 Antibody - H00057214-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: KIAA1199 Antibody [H00057214-B01P] - Analysis of KIAA1199 expression in transfected 293T cell line by KIAA1199 polyclonal antibody. Lane 1: KIAA1199 transfected lysate(109.12 KDa). Lane 2: Non-transfected lysate.

KIAA1199 Antibody (3C12) - H00057214-M01 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C12

KIAA1199 Antibody - H00057214-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

KIAA1199 Antibody - H00057214-D01 from Novus Biologicals

Prices	$399.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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