TSEN2

Gene Symbol	TSEN2
Entrez Gene	80746
Alt Symbol	PCH2B, SEN2, SEN2L
Species	Human
Gene Type	protein-coding
Description	TSEN2 tRNA splicing endonuclease subunit
Other Description	hsSen2|tRNA-intron endonuclease Sen2|tRNA-splicing endonuclease subunit Sen2
Swissprots	G5E9Q3 C9IZI7 Q9BPU7 Q8NCE0 Q8WTW7 B7Z6K1
Accessions	CAF86810 EAW64127 EAW64128 EAW64129 EAW64130 Q8NCE0 AF086155 AK027821 AK074794 BAC11213 AK225875 AK291183 BAF83872 AK295508 BAH12091 AK300449 BAH13287 BC004178 AAH04178 BC004211 AAH04211 BC019582 AAH19582 BC021975 AAH21975 BM671402 BX641631 CN341716 DA063377 DA484093 DA614108 HQ447904 ADQ32388 XM_005265495 XP_005265552 XM_005265497 XP_005265554 XM_005265498 XP_005265555 XM_005265499 XP_005265556 XM_011534138 XP_011532440 XM_011534139 XP_011532441 XM_011534140 XP_011532442 XR_245158 XR_245159 XR_427295 XR_427296 XR_940503 NM_001145392 NP_001138864 NM_001145393 NP_001138865 NM_001145394 NP_001138866 NM_001145395 NP_001138867 NM_025265 NP_079541
Function	Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA
Subcellular Location	Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.
Tissue Specificity	Isoform 1 and isoform 2 are widely expressed at very low level. {ECO:0000269|PubMed:15109492}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TSEN2 293T Cell Transient Overexpression Lysate(Denatured) - H00080746-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TSEN2 overexpression lysate - LY428858 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TSEN2 overexpression lysate - LY428859 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TSEN2 Overexpression Lysate (Denatured) - H00080746-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TSEN2 Overexpression Lysate (Native) - NBP2-06223 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TSEN2 Overexpression Lysate (Native) - NBP2-09746 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human TSEN2 Knockdown Stable Cell Line - CSC-DC016706 from Creative biogene Category Cell Line Species Human

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