TSEN2
| Gene Symbol | TSEN2 |
|---|---|
| Entrez Gene | 80746 |
| Alt Symbol | PCH2B, SEN2, SEN2L |
| Species | Human |
| Gene Type | protein-coding |
| Description | TSEN2 tRNA splicing endonuclease subunit |
| Other Description | hsSen2|tRNA-intron endonuclease Sen2|tRNA-splicing endonuclease subunit Sen2 |
| Swissprots | G5E9Q3 C9IZI7 Q9BPU7 Q8NCE0 Q8WTW7 B7Z6K1 |
| Accessions | CAF86810 EAW64127 EAW64128 EAW64129 EAW64130 Q8NCE0 AF086155 AK027821 AK074794 BAC11213 AK225875 AK291183 BAF83872 AK295508 BAH12091 AK300449 BAH13287 BC004178 AAH04178 BC004211 AAH04211 BC019582 AAH19582 BC021975 AAH21975 BM671402 BX641631 CN341716 DA063377 DA484093 DA614108 HQ447904 ADQ32388 XM_005265495 XP_005265552 XM_005265497 XP_005265554 XM_005265498 XP_005265555 XM_005265499 XP_005265556 XM_011534138 XP_011532440 XM_011534139 XP_011532441 XM_011534140 XP_011532442 XR_245158 XR_245159 XR_427295 XR_427296 XR_940503 NM_001145392 NP_001138864 NM_001145393 NP_001138865 NM_001145394 NP_001138866 NM_001145395 NP_001138867 NM_025265 NP_079541 |
| Function | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus. |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed at very low level. {ECO:0000269|PubMed:15109492}. |
Human TSEN2 full length protein - ab164284 from Abcam
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Human TSEN2 protein fragment - ab164285 from Abcam
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TSEN2 Antibody Blocking Peptide - LS-E6379 from LifeSpan Bioscience
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TSEN2 Antibody Blocking Peptide - LS-E22797 from LifeSpan Bioscience
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Recombinant Human TSEN2 Protein - H00080746-P01 from Novus Biologicals
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Recombinant Human TSEN2 Protein - H00080746-Q01 from Novus Biologicals
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TSEN2-Antibody-N-term-Blocking-Peptide - BP19095a from Abgent, a WuXi AppTec company
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TSEN2 / SEN2 - H00080746-P01-10 from Acris Antibodies
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TSEN2 / SEN2 - H00080746-P01-25 from Acris Antibodies
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TSEN2 / SEN2 - H00080746-Q01-10 from Acris Antibodies
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TSEN2 / SEN2 - H00080746-Q01-25 from Acris Antibodies
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TSEN2 fusion protein - ag3742 from Proteintech Group
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Recombinant Human tRNA-splicing endonuclease subunit Sen2(TSEN2) - CSB-YP850858HU CSB-EP850858HU CSB-BP850858HU CSB-MP850858HU from Cusabio
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TSEN2 Protein - abx164556 from Abbexa
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TSEN2 / SEN2 (transcript variant 1) - TP305156 from Acris Antibodies
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TSEN2 / SEN2 (transcript variant 2) - TP326917 from Acris Antibodies
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TSEN2 Recombinant Protein Antigen - NBP1-81142PEP from Novus Biologicals
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TSEN2 Recombinant Protein Antigen - NBP1-81141PEP from Novus Biologicals
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TSEN2 Recombinant Protein Antigen - NBP1-81140PEP from Novus Biologicals
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TSEN2 Peptide, Human - M34GP16706H from Creative Peptides
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