TSEN2
| Gene Symbol | TSEN2 |
|---|---|
| Entrez Gene | 80746 |
| Alt Symbol | PCH2B, SEN2, SEN2L |
| Species | Human |
| Gene Type | protein-coding |
| Description | TSEN2 tRNA splicing endonuclease subunit |
| Other Description | hsSen2|tRNA-intron endonuclease Sen2|tRNA-splicing endonuclease subunit Sen2 |
| Swissprots | G5E9Q3 C9IZI7 Q9BPU7 Q8NCE0 Q8WTW7 B7Z6K1 |
| Accessions | CAF86810 EAW64127 EAW64128 EAW64129 EAW64130 Q8NCE0 AF086155 AK027821 AK074794 BAC11213 AK225875 AK291183 BAF83872 AK295508 BAH12091 AK300449 BAH13287 BC004178 AAH04178 BC004211 AAH04211 BC019582 AAH19582 BC021975 AAH21975 BM671402 BX641631 CN341716 DA063377 DA484093 DA614108 HQ447904 ADQ32388 XM_005265495 XP_005265552 XM_005265497 XP_005265554 XM_005265498 XP_005265555 XM_005265499 XP_005265556 XM_011534138 XP_011532440 XM_011534139 XP_011532441 XM_011534140 XP_011532442 XR_245158 XR_245159 XR_427295 XR_427296 XR_940503 NM_001145392 NP_001138864 NM_001145393 NP_001138865 NM_001145394 NP_001138866 NM_001145395 NP_001138867 NM_025265 NP_079541 |
| Function | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus. |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed at very low level. {ECO:0000269|PubMed:15109492}. |
TSEN2 CRISPR/Cas9 KO Plasmid (h) - sc-409499 from Santa Cruz Biotechnology
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TSEN2 HDR Plasmid (h) - sc-409499-HDR from Santa Cruz Biotechnology
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TSEN2 Double Nickase Plasmid (h) - sc-409499-NIC from Santa Cruz Biotechnology
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TSEN2 Double Nickase Plasmid (h2) - sc-409499-NIC-2 from Santa Cruz Biotechnology
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TSEN2 CRISPR Activation Plasmid (h) - sc-409499-ACT from Santa Cruz Biotechnology
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TSEN2 CRISPR Activation Plasmid (h2) - sc-409499-ACT-2 from Santa Cruz Biotechnology
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TSEN2 Lentiviral Activation Particles (h) - sc-409499-LAC from Santa Cruz Biotechnology
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TSEN2 Lentiviral Activation Particles (h2) - sc-409499-LAC-2 from Santa Cruz Biotechnology
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TSEN2 siRNA (h) - sc-78520 from Santa Cruz Biotechnology
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TSEN2 shRNA Plasmid (h) - sc-78520-SH from Santa Cruz Biotechnology
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TSEN2 shRNA (h) Lentiviral Particles - sc-78520-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU065661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22079 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22079 from Sigma-Aldrich
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TSEN2 siRNA (Human) - CRJ2898 from Cohesion Biosciences
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TSEN2 RNAi - H00080746-R01 from Novus Biologicals
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TSEN2 - MBS8218003 from MyBioSource
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shRNA set against Human SEN2 (NM_025265.3) - SHH404436 from Creative biogene
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Human TSEN2 siRNA - orb273399 from Biorbyt
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TSEN2 shRNA Plasmid (Human) - CHJ2898 from Cohesion Biosciences
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TSEN2 miRNA 3'UTR clone - MiUTR3H-10200 from Creative biogene
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TSEN2 miRNA 3'UTR clone - MiUTR3H-10201 from Creative biogene
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TSEN2 miRNA 3'UTR clone - MiUTR3H-10202 from Creative biogene
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TSEN2 miRNA 3'UTR clone - MiUTR3H-10203 from Creative biogene
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TSEN2 miRNA 3'UTR clone - MiUTR3H-10204 from Creative biogene
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