| Gene Symbol |
KISS1
|
| Entrez Gene |
3814
|
| Alt Symbol |
HH13, KiSS-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KiSS-1 metastasis-suppressor
|
| Other Description |
kisspeptin-1|malignant melanoma metastasis-suppressor|metastasis-suppressor KiSS-1|metastin|prepro-kisspeptin
|
| Swissprots |
A8K6N0 Q9HBP1 Q15726
|
| Accessions |
CBH19336 EAW91506 EAW91507 Q15726 AF218017 AAG17259 AK291695 BAF84384 AY117143 AAM78592 BC022819 AAH22819 DQ892799 ABM83725 DQ896046 ABM87045 U43527 AAC79512 XM_011509525 XP_011507827 NM_002256 NP_002247
|
| Function |
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis a
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.
|