KISS1

Gene Symbol KISS1
Entrez Gene 3814
Alt Symbol HH13, KiSS-1
Species Human
Gene Type protein-coding
Description KiSS-1 metastasis-suppressor
Other Description kisspeptin-1|malignant melanoma metastasis-suppressor|metastasis-suppressor KiSS-1|metastin|prepro-kisspeptin
Swissprots A8K6N0 Q9HBP1 Q15726
Accessions CBH19336 EAW91506 EAW91507 Q15726 AF218017 AAG17259 AK291695 BAF84384 AY117143 AAM78592 BC022819 AAH22819 DQ892799 ABM83725 DQ896046 ABM87045 U43527 AAC79512 XM_011509525 XP_011507827 NM_002256 NP_002247
Function Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis a
Subcellular Location Secreted.
Tissue Specificity Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.

KiSS-1 (FL-145) - sc-15400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

KiSS-1 (C-20) - sc-18134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KiSS-1 (C-20): sc-18134. Western blot analysis of KiSS-1 expression in mouse testis tissue extract.

KiSS-1 (R-20) - sc-18133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KiSS-1 (24-Q) - sc-101246 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
KiSS-1 (24-Q): sc-101246. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate tissue showing nuclear and cytoplasmic localization.

Anti-Kisspeptin antibody - ab80994 from Abcam

Prices $379.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab80994 stained JEG-3 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab80994, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Kisspeptin antibody - ab19028 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Kisspeptin antibody (ab19028) at 1 µg/ml + Jurkat cell lysate (30ug)

Anti-Kisspeptin antibody - ab55384 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Kisspeptin antibody (ab55384) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human prostate.

Anti-Kisspeptin antibody - ab72804 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab72804 at 1/100 dilution staining Kisspeptin in human placenta by Immunohistochemistry, Paraffin-embedded tissue.

Anti-Kisspeptin antibody - ab101017 from Abcam

Prices $372.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Kisspeptin antibody - ab172012 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Kisspeptin antibody (ab172012) at 1 µg/mlLane 1 : Kisspeptin transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.

Anti-KISS1 / Kisspeptin / Metastin Antibody (N-Terminus) - LS-C48546 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (N-Terminus) - LS-C94226 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (Internal) - LS-C145138 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (phospho-Tyr112) - LS-C153491 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (aa17) - LS-C189441 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (aa112-121) - LS-C191040 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (aa68-121) - LS-C191041 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (aa68-92) - LS-C191042 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (aa94-121) - LS-C191043 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody - LS-C310821 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (aa46-146, Azide-free) - LS-C330535 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody - LS-C341516 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1 / Kisspeptin / Metastin Antibody (clone 1F7) - LS-C133279 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F7
Western blot of KISS1 expression in transfected 293T cell line by KISS1 monoclonal antibody (M05), clone 1F7.

Anti-KISS1 / Kisspeptin / Metastin Antibody - LS-C332313 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded Human brain tissue using KISS1 antibody.

KISS1 Antibody - NBP1-45672 from Novus Biologicals

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: KISS1 Antibody [NBP1-45672] - Analysis of KiSS-1 expression with Jurkat Cell Lysate.
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