KISS1

Gene Symbol	KISS1
Entrez Gene	3814
Alt Symbol	HH13, KiSS-1
Species	Human
Gene Type	protein-coding
Description	KiSS-1 metastasis-suppressor
Other Description	kisspeptin-1|malignant melanoma metastasis-suppressor|metastasis-suppressor KiSS-1|metastin|prepro-kisspeptin
Swissprots	A8K6N0 Q9HBP1 Q15726
Accessions	CBH19336 EAW91506 EAW91507 Q15726 AF218017 AAG17259 AK291695 BAF84384 AY117143 AAM78592 BC022819 AAH22819 DQ892799 ABM83725 DQ896046 ABM87045 U43527 AAC79512 XM_011509525 XP_011507827 NM_002256 NP_002247
Function	Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis a
Subcellular Location	Secreted.
Tissue Specificity	Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kisspeptin full length protein - ab117209 from Abcam Category Protein Source E. coli Species Human

Human Kisspeptin protein fragment - ab78765 from Abcam Category Protein Source E. coli Species Human

Kisspeptin peptide - ab37702 from Abcam Category Peptide

KISS1 Partial Recombinant Protein - H00003814-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

KISS1 Recombinant Protein - H00003814-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human KISS1 Protein - NBC1-18516 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

KISS1 Blocking Peptide - NBP1-45672PEP from Novus Biologicals Category Peptide Prices $95.00 Sizes 50 µg

Kisspeptin-13 - SP2925b from Abgent, a WuXi AppTec company Category Peptide Prices $165.00 Sizes 1 mg

Kisspeptin-13 - SP2925a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 500 µg

Kisspeptin-10-Metastin-45-54-Human - SP3446b from Abgent, a WuXi AppTec company Category Peptide Prices $198.00 Sizes 1 mg Species Human

Kisspeptin-10-Metastin-45-54-Human - SP3446a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 500 µg Species Human

KISS1 Protein (OPPA01749) - OPPA01749 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human KISS1 protein - orb81180 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Kiss-1 peptide - orb72905 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

KiSS1 Blocking Peptide - 33R-10819 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

KISS1 protein - 30R-1202 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

KiSS-1 (1-120) - AR09057PU-L from Acris Antibodies Category Protein Prices $785.00 Sizes 500 µg Source E. coli Species Human

KiSS-1 (1-120) - AR09057PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

KiSS-1 - H00003814-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

KiSS-1 - H00003814-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KiSS-1 - H00003814-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KiSS-1 Control Peptide - AP00261CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg Species Human

KISS-1 Metastasis-Suppressor, Human Recombinant - 228-10995-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human KISS1 - 228-10995-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human KISS1 - 228-10995-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

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