| Gene Symbol |
CD40LG
|
| Entrez Gene |
959
|
| Alt Symbol |
CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD40 ligand
|
| Other Description |
CD40 antigen ligand|CD40-L|T-B cell-activating molecule|T-cell antigen Gp39|TNF-related activation protein|tumor necrosis factor (ligand) superfamily member 5
|
| Swissprots |
P29965
|
| Accessions |
AAC41932 AAZ23548 ABK41936 BAA06599 CAH25976 CAL44882 CAL99223 CAL99228 CAY55957 CBY45341 EAW88462 EAW88463 P29965 AF529195 AAQ09090 AK292637 BAF85326 AY197739 AAP37943 BC071754 AAH71754 BC074950 AAH74950 FN298241 CAX65629 HQ447532 ADQ32018 L07414 AAA35662 S66178 AAD13982 X67878 CAA48077 X68550 CAA48554 X96710 Z15017 CAA78737 NM_000074 NP_000065
|
| Function |
Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269|PubMed:15193700}.
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Specifically expressed on activated CD4+ T- lymphocytes.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Primary immunodeficiency, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production
|
![Western Blot: CD40 Ligand Overexpression Lysate (Adult Normal) [NBL1-08949] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CD40 Ligand.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4442_CD40%2520Ligand%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08949-img0002.jpg)
![Immunohistochemistry: CD40 Ligand/TNFSF5 Lysate [DDX-S2-2] - PBMC culturedin the presence of DDX-S2](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26178_CD40-Ligand-TNFSF5-Lysate-Immunohistochemistry-DDX-S2-2-img0004.jpg)