Gene Symbol | CD40LG |
---|---|
Entrez Gene | 959 |
Alt Symbol | CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L |
Species | Human |
Gene Type | protein-coding |
Description | CD40 ligand |
Other Description | CD40 antigen ligand|CD40-L|T-B cell-activating molecule|T-cell antigen Gp39|TNF-related activation protein|tumor necrosis factor (ligand) superfamily member 5 |
Swissprots | P29965 |
Accessions | AAC41932 AAZ23548 ABK41936 BAA06599 CAH25976 CAL44882 CAL99223 CAL99228 CAY55957 CBY45341 EAW88462 EAW88463 P29965 AF529195 AAQ09090 AK292637 BAF85326 AY197739 AAP37943 BC071754 AAH71754 BC074950 AAH74950 FN298241 CAX65629 HQ447532 ADQ32018 L07414 AAA35662 S66178 AAD13982 X67878 CAA48077 X68550 CAA48554 X96710 Z15017 CAA78737 NM_000074 NP_000065 |
Function | Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269|PubMed:15193700}. |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. |
Tissue Specificity | Specifically expressed on activated CD4+ T- lymphocytes. |
Top Pathways | Cytokine-cytokine receptor interaction, Primary immunodeficiency, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production |
CD154 CRISPR/Cas9 KO Plasmid (h) - sc-401682 from Santa Cruz Biotechnology
|
||||||||
CD154 HDR Plasmid (h) - sc-401682-HDR from Santa Cruz Biotechnology
|
||||||||
CD154 Double Nickase Plasmid (h) - sc-401682-NIC from Santa Cruz Biotechnology
|
||||||||
CD154 Double Nickase Plasmid (h2) - sc-401682-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CD154 CRISPR Activation Plasmid (h) - sc-401682-ACT from Santa Cruz Biotechnology
|
||||||||
CD154 CRISPR Activation Plasmid (h2) - sc-401682-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CD154 Lentiviral Activation Particles (h) - sc-401682-LAC from Santa Cruz Biotechnology
|
||||||||
CD154 Lentiviral Activation Particles (h2) - sc-401682-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CD154 siRNA (h) - sc-29965 from Santa Cruz Biotechnology
|
||||||||
CD154 shRNA Plasmid (h) - sc-29965-SH from Santa Cruz Biotechnology
|
||||||||
CD154 shRNA (h) Lentiviral Particles - sc-29965-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU138531 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5731 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5731 from Sigma-Aldrich
|
||||||||
CD40LG siRNA (Human) - CRH0681 from Cohesion Biosciences
|
||||||||
CD40 Ligand/TNFSF5 RNAi - H00000959-R01 from Novus Biologicals
|
||||||||
CD40LG - MBS8210197 from MyBioSource
|
||||||||
shRNA set against Human CD40LG (NM_000074.2) - SHH259117 from Creative biogene
|
||||||||
shRNA set against Human CD40LG(NM_000074.2) - SHG157483 from Creative biogene
|
||||||||
CD40LG shRNA Plasmid (Human) - CHH0681 from Cohesion Biosciences
|
||||||||
CD40LG miRNA 3'UTR clone - MiUTR1H-01879 from Creative biogene
|