| Gene Symbol |
TICAM1
|
| Entrez Gene |
148022
|
| Alt Symbol |
IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
toll-like receptor adaptor molecule 1
|
| Other Description |
TIR domain containing adaptor inducing interferon-beta|TIR domain-containing adapter molecule 1|TIR domain-containing adapter protein inducing IFN-beta|proline-rich, vinculin and TIR domain-containing protein B|putative NF-kappa-B-activating protein 502H|toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
|
| Swissprots |
O75532 B3Y691 Q8IUC6 Q86XP8 Q96GA0
|
| Accessions |
CAH56797 Q8IUC6 AB086380 BAC55579 AB093555 BAC44839 AB097023 BAC77376 AB446484 BAG55261 AF070530 AAC28630 AF492646 AAO85488 BC009860 AAH09860 BC035331 BC136556 AAI36557 BC136557 AAI36558 BX349282 CA308725 DR000002 NM_182919 NP_891549 NM_014261
|
| Function |
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}.
|
| Tissue Specificity |
Ubiquitously expressed but with higher levels in liver. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043}.
|
| Top Pathways |
Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Hepatitis C, Pertussis, Influenza A
|