TICAM1

Gene Symbol TICAM1
Entrez Gene 148022
Alt Symbol IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Species Human
Gene Type protein-coding
Description toll-like receptor adaptor molecule 1
Other Description TIR domain containing adaptor inducing interferon-beta|TIR domain-containing adapter molecule 1|TIR domain-containing adapter protein inducing IFN-beta|proline-rich, vinculin and TIR domain-containing protein B|putative NF-kappa-B-activating protein 502H|toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Swissprots O75532 B3Y691 Q8IUC6 Q86XP8 Q96GA0
Accessions CAH56797 Q8IUC6 AB086380 BAC55579 AB093555 BAC44839 AB097023 BAC77376 AB446484 BAG55261 AF070530 AAC28630 AF492646 AAO85488 BC009860 AAH09860 BC035331 BC136556 AAI36557 BC136557 AAI36558 BX349282 CA308725 DR000002 NM_182919 NP_891549 NM_014261
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}.
Tissue Specificity Ubiquitously expressed but with higher levels in liver. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043}.
Top Pathways Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Hepatitis C, Pertussis, Influenza A

TRIF Antibody - 4596 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cells, mock transfected or transfected with human TRIF, and from Raji, MOLT-4 and SR cell lines using TRIF Antibody.

TICAM-1 (E-7) - sc-514384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TICAM-1 (E-7): sc-514384. Western blot analysis of TICAM-1 expression in Hep G2 whole cell lysate.

TICAM-1 (C-14) - sc-130621 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

TICAM-1 (P-15) - sc-27478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRIF antibody - ab101232 from Abcam

Prices $385.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
IHC image of TRIF staining in human liver formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab101232, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TRIF antibody - ab62583 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TRIF antibody (ab62583) at 2 µg/mlLane 2 : Anti-TRIF antibody (ab62583) at 4 µg/mlLane 1 : Human lung cell lysatesLane 2 : Human lung cell lysatesLysates/proteins at 15 µg per lane.

Anti-TRIF antibody - ab13810 from Abcam

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of TICAM in mouse spleen lysate using ab13810 at 1:1000 dilution.

Anti-TRIF antibody [1G7] - ab139281 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G7
All lanes : Anti-TRIF antibody [1G7] (ab139281) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY TRIFLysates/proteins at 5 µg per lane.

Anti-TICAM1 / TRIF Antibody (aa692-712) - LS-C313040 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TICAM1 / TRIF antibody. IHC(P): Human Breast Cancer Tissue.

Anti-TICAM1 / TRIF Antibody (C-Terminus) IHC-plus™ - LS-B1412 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TICAM1 / TRIF antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1412 concentration 5 ug/ml.

Anti-TICAM1 / TRIF Antibody (C-Terminus) - LS-C10571 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TICAM1 / TRIF Antibody (aa143-158) - LS-C92839 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM1 / TRIF Antibody (aa29-204) - LS-C132509 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TICAM1 / TRIF Antibody (aa474-618, clone TS106) - LS-C191497 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TS106

Anti-TICAM1 / TRIF Antibody (C-Terminus) - LS-C209795 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM1 / TRIF Antibody (Internal) - LS-C209807 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM1 / TRIF Antibody (aa4-31) - LS-C344842 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TICAM1 / TRIF Antibody - LS-C192408 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of TICAM1 pAb in extracts from mouse lung tissue.

Anti-TICAM1 / TRIF Antibody (aa143-158) - LS-C749 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot of TICAM1 in mouse spleen lysate using antibody at 1:1000 dilution.

Anti-TICAM1 / TRIF Antibody (aa115-143) - LS-C203948 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TICAM1 Antibody western blot of Ramos cell line and mouse liver tissue lysates (35 ug/lane). The TICAM1 antibody detected the TICAM1 protein (arrow).

Anti-TICAM1 / TRIF Antibody - LS-C331302 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of lung cell lysate using TICAM1 antibody.

Anti-TICAM1 / TRIF Antibody (aa693-708) - LS-C313133 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of TICAM1 / TRIF antibody. Recombinant Protein Detection Source:. E.coli derived -recombinant Mouse TICAM1,37.5KD. (162aa tag+ L551-E732). Lane 1: Recombinant Mouse TICAM1 Protein 10ng. Lane 2: Recombinant Mouse TICAM1 Protein 5ng. Lane 3: Recombinant Mouse TICAM1 Protein 2.5ng. Lane 4: Recombinant Mouse TICAM1 Protein 1.25ng.

Anti-TICAM1 / TRIF Antibody IHC-plus™ - LS-B632 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TICAM1 / TRIF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B632 concentration 5 ug/ml.

Anti-TICAM1 / TRIF Antibody (clone 1G7) - LS-C175438 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G7
Western blot of extracts (35 ug) from 9 different cell lines by using anti-TICAM1 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

Anti-TICAM1 / TRIF Antibody (C-Terminus) IHC-plus™ - LS-B754 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TICAM1 / TRIF antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B754 concentration 10 ug/ml.
Search more