TICAM1

Gene Symbol TICAM1
Entrez Gene 148022
Alt Symbol IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Species Human
Gene Type protein-coding
Description toll-like receptor adaptor molecule 1
Other Description TIR domain containing adaptor inducing interferon-beta|TIR domain-containing adapter molecule 1|TIR domain-containing adapter protein inducing IFN-beta|proline-rich, vinculin and TIR domain-containing protein B|putative NF-kappa-B-activating protein 502H|toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Swissprots O75532 B3Y691 Q8IUC6 Q86XP8 Q96GA0
Accessions CAH56797 Q8IUC6 AB086380 BAC55579 AB093555 BAC44839 AB097023 BAC77376 AB446484 BAG55261 AF070530 AAC28630 AF492646 AAO85488 BC009860 AAH09860 BC035331 BC136556 AAI36557 BC136557 AAI36558 BX349282 CA308725 DR000002 NM_182919 NP_891549 NM_014261
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}.
Tissue Specificity Ubiquitously expressed but with higher levels in liver. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043}.
Top Pathways Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Hepatitis C, Pertussis, Influenza A

TICAM-1 CRISPR/Cas9 KO Plasmid (h) - sc-414627 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 HDR Plasmid (h) - sc-414627-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 Double Nickase Plasmid (h) - sc-414627-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 Double Nickase Plasmid (h2) - sc-414627-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 CRISPR Activation Plasmid (h) - sc-414627-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 CRISPR Activation Plasmid (h2) - sc-414627-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 Lentiviral Activation Particles (h) - sc-414627-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 Lentiviral Activation Particles (h2) - sc-414627-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 siRNA (h) - sc-106845 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TICAM-1 shRNA Plasmid (h) - sc-106845-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TICAM-1 shRNA (h) Lentiviral Particles - sc-106845-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIF/TICAM1 RNAi - H00148022-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN21342 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21342 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TICAM1 siRNA (Human) - CRJ5561 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIF/TICAM1 RNAi - H00148022-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TICAM1 - MBS8224918 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TICAM1 (NM_182919.3) - SHH427232 from Creative biogene

Category siRNA
Species Reactivities Human

TICAM-1 CRISPR/Cas9 KO Plasmid (h2) - sc-414627-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM-1 HDR Plasmid (h2) - sc-414627-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TICAM1 shRNA Plasmid (Human) - CHJ5561 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TICAM1 miRNA 3'UTR clone - MiUTR3H-09337 from Creative biogene

Species Reactivities Human
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