Gene Symbol | TICAM1 |
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Entrez Gene | 148022 |
Alt Symbol | IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF |
Species | Human |
Gene Type | protein-coding |
Description | toll-like receptor adaptor molecule 1 |
Other Description | TIR domain containing adaptor inducing interferon-beta|TIR domain-containing adapter molecule 1|TIR domain-containing adapter protein inducing IFN-beta|proline-rich, vinculin and TIR domain-containing protein B|putative NF-kappa-B-activating protein 502H|toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta |
Swissprots | O75532 B3Y691 Q8IUC6 Q86XP8 Q96GA0 |
Accessions | CAH56797 Q8IUC6 AB086380 BAC55579 AB093555 BAC44839 AB097023 BAC77376 AB446484 BAG55261 AF070530 AAC28630 AF492646 AAO85488 BC009860 AAH09860 BC035331 BC136556 AAI36557 BC136557 AAI36558 BX349282 CA308725 DR000002 NM_182919 NP_891549 NM_014261 |
Function | Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}. |
Tissue Specificity | Ubiquitously expressed but with higher levels in liver. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043}. |
Top Pathways | Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Hepatitis C, Pertussis, Influenza A |
TICAM-1 CRISPR/Cas9 KO Plasmid (h) - sc-414627 from Santa Cruz Biotechnology
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TICAM-1 HDR Plasmid (h) - sc-414627-HDR from Santa Cruz Biotechnology
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TICAM-1 Double Nickase Plasmid (h) - sc-414627-NIC from Santa Cruz Biotechnology
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TICAM-1 Double Nickase Plasmid (h2) - sc-414627-NIC-2 from Santa Cruz Biotechnology
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TICAM-1 CRISPR Activation Plasmid (h) - sc-414627-ACT from Santa Cruz Biotechnology
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TICAM-1 CRISPR Activation Plasmid (h2) - sc-414627-ACT-2 from Santa Cruz Biotechnology
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TICAM-1 Lentiviral Activation Particles (h) - sc-414627-LAC from Santa Cruz Biotechnology
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TICAM-1 Lentiviral Activation Particles (h2) - sc-414627-LAC-2 from Santa Cruz Biotechnology
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TICAM-1 siRNA (h) - sc-106845 from Santa Cruz Biotechnology
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TICAM-1 shRNA Plasmid (h) - sc-106845-SH from Santa Cruz Biotechnology
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TICAM-1 shRNA (h) Lentiviral Particles - sc-106845-V from Santa Cruz Biotechnology
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TRIF/TICAM1 RNAi - H00148022-R04 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21342 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21342 from Sigma-Aldrich
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TICAM1 siRNA (Human) - CRJ5561 from Cohesion Biosciences
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TRIF/TICAM1 RNAi - H00148022-R03 from Novus Biologicals
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TICAM1 - MBS8224918 from MyBioSource
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shRNA set against Human TICAM1 (NM_182919.3) - SHH427232 from Creative biogene
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TICAM-1 CRISPR/Cas9 KO Plasmid (h2) - sc-414627-KO-2 from Santa Cruz Biotechnology
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TICAM-1 HDR Plasmid (h2) - sc-414627-HDR-2 from Santa Cruz Biotechnology
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TICAM1 shRNA Plasmid (Human) - CHJ5561 from Cohesion Biosciences
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TICAM1 miRNA 3'UTR clone - MiUTR3H-09337 from Creative biogene
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