TICAM1

Gene Symbol	TICAM1
Entrez Gene	148022
Alt Symbol	IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Species	Human
Gene Type	protein-coding
Description	toll-like receptor adaptor molecule 1
Other Description	TIR domain containing adaptor inducing interferon-beta|TIR domain-containing adapter molecule 1|TIR domain-containing adapter protein inducing IFN-beta|proline-rich, vinculin and TIR domain-containing protein B|putative NF-kappa-B-activating protein 502H|toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Swissprots	O75532 B3Y691 Q8IUC6 Q86XP8 Q96GA0
Accessions	CAH56797 Q8IUC6 AB086380 BAC55579 AB093555 BAC44839 AB097023 BAC77376 AB446484 BAG55261 AF070530 AAC28630 AF492646 AAO85488 BC009860 AAH09860 BC035331 BC136556 AAI36557 BC136557 AAI36558 BX349282 CA308725 DR000002 NM_182919 NP_891549 NM_014261
Function	Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}.
Tissue Specificity	Ubiquitously expressed but with higher levels in liver. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043}.
Top Pathways	Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Hepatitis C, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIF protein fragment - ab153605 from Abcam Category Protein Source Wheat germ Species Human

TICAM1 / TRIF Antibody Blocking Peptide - LS-E30030 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIF/TICAM1 Blocking Peptide - NBP1-77221PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human TRIF/TICAM1 Protein - H00148022-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TICAM1 / TRIF - H00148022-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TICAM1 / TRIF - H00148022-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TICAM1 / TRIF Control Peptide - AP10360CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

TICAM1 / TRIF Control Peptide - AP30945CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRIF Peptide - 3173P from ProSci Category Peptide Species Human

TICAM1 fusion protein - ag19779 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TICAM1 fusion protein - ag19769 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Toll Like Receptor Adaptor Molecule 1 (TICAM1) - RPH022Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Toll Like Receptor Adaptor Molecule 1 (TICAM1) - RPH022Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Toll Like Receptor Adaptor Molecule 1 (TICAM1) - RPH022Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human TIR domain-containing adapter molecule 1(TICAM1) - CSB-YP811598HU CSB-EP811598HU CSB-BP811598HU CSB-MP811598HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRIF/TICAM1 Recombinant Protein Antigen - NBP1-89566PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TICAM1-Blocking-Peptide-N-term - BP20485a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TICAM1 Peptide, Human - M34GP15940H from Creative Peptides Category Peptide Source Synthetic. Species Human

TRIF Blocking Peptide - CBP7494 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

human TICAM1 protein - orb54743 from Biorbyt Category Protein Prices $893.00, $1,003.00, $1,564.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Recombinant Human TIR domain-containing adapter molecule 1(TICAM1) - CSB-CF811598HU from Cusabio Category Protein Source in vitro E.coli expression system Species Human

TICAM1 Recombinant Protein (OPCD07435) - OPCD07435 from Aviva Systems Biology Category Protein Source E.coli Species Human

TICAM1 Recombinant Protein (Human) (OPCA05371) - OPCA05371 from Aviva Systems Biology Category Protein Species Human

TICAM1 Recombinant Protein (Human) (OPCA05372) - OPCA05372 from Aviva Systems Biology Category Protein Species Human

Recombinant Human TIR domain-containing adapter molecule 1 (TICAM1) - RPC20813 from Biomatik Category Protein Prices $1,489.00 Sizes 1 mg Source in vitro E.coli expression system Species Human

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